ORs of new-onset T2DM associated with the levels of apolipoprotein Cs
| All participants (n=1085) | Participants without IFG at baseline (n=1069) | |||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Apolipoprotein C-II | ||||
| Unadjusted | 1.54 (1.22 to 1.95) | <0.001 | 1.54 (1.20 to 1.98) | <0.001 |
| Model 1 | 1.54 (1.22 to 1.95) | <0.001 | 1.56 (1.21 to 2.00) | <0.001 |
| Model 2 | 1.34 (1.04 to 1.73) | 0.023 | 1.30 (1.00 to 1.69) | 0.054 |
| Model 3 | 1.40 (1.08 to 1.81) | 0.011 | 1.36 (1.04 to 1.79) | 0.026 |
| Model 4 | 1.25 (0.95 to 1.66) | 0.117 | 1.21 (0.90 to 1.62) | 0.203 |
| Apolipoprotein C-III | ||||
| Unadjusted | 1.66 (1.33 to 2.08) | <0.001 | 1.65 (1.30 to 2.08) | <0.001 |
| Model 1 | 1.71 (1.36 to 2.14) | <0.001 | 1.70 (1.34 to 2.16) | <0.001 |
| Model 2 | 1.54 (1.21 to 1.96) | <0.001 | 1.48 (1.15 to 1.91) | 0.002 |
| Model 3 | 1.59 (1.25 to 2.03) | <0.001 | 1.54 (1.19 to 1.99) | 0.001 |
| Model 4 | 1.40 (1.07 to 1.82) | 0.013 | 1.40 (1.06 to 1.84) | 0.019 |
Model 1: adjusted for age (per 1 year), sex and parental history for diabetes.
Model 2: model 1+ overweight, hypertension, current smoking and current drinking, physical activity, lipid-lowering treatment, low-density lipoprotein cholesterol levels (per 1 mg/dL) and, high-density lipoprotein cholesterol (per 1 mg/dL).
Model 3: model 2+ naturally log-transformed high-sensitivity C reactive protein.
Model 4: model 3+ fasting blood glucose levels (per 1 mg/dL).
The ORs and corresponding CIs for 1 SD increases in naturally log-transformed apolipoprotein C-II or apolipoprotein C-III were calculated using the logistic regression model.
IFG, impaired fasting glucose; T2DM, type 2 diabetes mellitus.