Table 3

Multivariable Fine and Gray model for baseline characteristics, laboratory parameters and inflammatory biomarkers

Variables
Multivariable analysis (model A)Multivariable analysis (model B)
MortalityDischarged aliveMortalityDischarged alive
SHR95% CIP valueSHR95% CIP valueSHR95% CIP valueSHR95% CIP value
Age≤401.001.001.001.00
41–591.230.60 to 2.490.5721.030.81 to 1.320.8251.550.65 to 3.710.3250.950.74 to 1.210.671
≥601.440.67 to 3.090.3470.940.70 to 1.260.6751.720.67 to 4.460.2610.780.57 to 1.060.110
ComorbiditiesNo comorbidities1.001.001.001.00
11.200.69 to 2.100.5150.910.72 to 1.140.4071.310.59 to 2.910.5090.870.67 to 1.110.254
2 or more1.761.02 to 3.030.0410.890.69 to 1.140.3292.681.26 to 5.700.0110.690.52 to 0.930.014
Neutrophil/lymphocyte ratio*<51.001.00
5–103.341.21 to 9.190.0200.810.64 to 1.030.095
>109.973.65 to 27.13<0.0010.390.26 to 0.58<0.001
SOFA score*1.221.11 to 1.35<0.0010.750.68 to 0.83<0.001
D-dimer (mg/L)†<0.51.00
0.5–1.01.290.54 to 3.100.5650.840.65 to 1.090.198
>1.02.501.14 to 5.480.0220.640.49 to 0.82<0.001
Ferritin (ng/mL)†<5001.001.00
≥5002.671.44 to 4.960.0020.690.55 to 0.860.001
LDH† (IU/L)<4501.001.00
≥4502.961.60 to 5.450.0010.680.55 to 0.850.001
PaO2/FiO2*<100 (severe)3.471.64 to 7.370.0013.1e-071.7e-07 to 5.7e-07<0.001
100–200 (moderate)1.910.91 to 4.0040.0870.4010.19 to 0.850.016
>200 (mild)1.001.00
  • (Model A) Multivariable Fine and Gray model for age, comorbidities with laboratory parameters.

  • (Model B) Multivariable Fine and Gray model for age, comorbidities with inflammatory biomarker values.

  • P values are highlighted in bold for statistically significant factors.

  • *Laboratory parameters were measured at days 0, 1, 3, 5, 7 and day 14.

  • †Inflammatory biomarker values were measured at days 0, 3 and day 7.

  • LDH, lactate dehydrogenase; SHR, subdistribution HR; ;SOFA, Sequential Organ Failure Assessment.