Study measures
| Study measure | Instrument | T0 | T1 | T2 |
| Potential predictors | ||||
| Malnutrition | PG-SGA | ✓ | ✓ | ✓ |
| Muscle strength | Handgrip dynamometer | ✓ | ✓ | ✓ |
| Bioimpedence spectroscopy | Total body and appendicular (arms+legs) fat-free mass, fat mass | ✓ | ✓ | ✓ |
| Physical activity and sedentary behaviour | Accelerometer, inclinometer, IPAQ-short form | ✓ | ✓ | ✓ |
| Physical performance | SPPB | ✓ | ✓ | ✓ |
| Sarcopenia risk | SARC-F, calf-circumference | ✓ | ✓ | ✓ |
| Protein and energy intake | 3-day food record | ✓ | ✓ | ✓ |
| Systemic inflammation | Neutrophil to lymphocyte ratio | ✓ | ✓ | ✓ |
| Primary outcome | ||||
| Muscle mass | CT | ✓ | x | ✓ |
| Secondary outcomes | ||||
| Muscle attenuation | CT | ✓ | x | ✓ |
| Visceral, subcutaneous and intramuscular adipose tissue | ✓ | x | ✓ | |
| Treatment completion | Medical record | x | x | ✓ |
| Toxicities | CTCAE V.5.0 | ✓ | ✓ | ✓ |
| Survival | Medical record or death registry | 12 months post final recruitment | ||
CTCAE, Common Terminology Criteria for Adverse Events; IPAQ, International Physical Activity Questionnaire-short form; PG-SGA, Patient-Generated Subjective Global Assessment; SARC-F, Strength, Assistance in walking, Rise from a chair, Climb stairs, Falls history; SPPB, short physical performance battery.