Table 6

Minimum number of patients needed in each cohort and overall, assuming a 95% confidence level and 5% margin of error for the percentage of cases changed

CohortExpected percentage of cases changedNumber of patients needed in cohortPercentage of overall sample in cohortTotal sample size needed
Stage II patients34*34545767
Stage III patients46*38255695
Patients with (−) ctDNA result2528977.25375
  • *Based on the highest percentage of cases changed within each stage from table 4.

  • ctDNA, circulating tumour DNA.