Population | Index prognostic factor | Comparator | Outcome(s) | Timing | Setting |
Adults with sepsis | Sex | Non-applicable to this review* | Primary outcomes | ICUs | |
All-cause hospital mortality | The longest follow-up provided by the study authors (until death of hospital discharge) | ||||
28-day all-cause mortality | 28 days from sepsis diagnosis | ||||
Secondary outcomes | |||||
7-day all-cause hospital mortality | 7 days from sepsis diagnosis | ||||
1-year all-cause mortality | 1 year from sepsis diagnosis | ||||
All-cause ICU mortality | The longest follow-up provided by the study authors (until death of ICU discharge) |
*Core set of adjustment factors: age, severity score (Sequential Organ Failure Assessment score, Simplified Acute Physiology Score II or Acute Physiologic Assessment and Chronic Health Evaluation II), comorbidities (immunosuppression, pulmonary diseases, cancer, liver diseases or alcohol dependence), non-urinary source of infection and inappropriate or late antibiotic coverage.
ICUs, intensive care units; PICOTS, population, index, comparator, outcome(s), timing, setting.