Table 3

The joint effect of eGFR and urine protein with cardiovascular mortality

VariablesCardiovascular mortality
MaleFemale
HR (95% CI)P valueHR (95% CI)P value
eGFR ≥90 + urine protein (−)RefRef
90>eGFR≥60+ urine protein (−)1.93 (0.79 to 4.71)0.1482.84 (0.90 to 9.00)0.076
60>eGFR≥45+ urine protein (−)2.92 (1.19 to 7.15)0.0194.14 (1.29 to 13.3)0.017
eGFR<45+ urine protein (−)3.80 (1.53 to 9.46)0.0046.88 (2.10 to 22.5)0.001
eGFR ≥90+ urine protein (+/−, +, ++)1.57 (0.30 to 8.08)0.5913.27 (0.34 to 31. 5)0.305
90>eGFR≥60+ urine protein (+/−, +, ++)2.85 (1.14 to 7.10)0.0254.72 (1.44 to 15.5)0.011
60>eGFR≥45+ urine protein (+/−, +, ++)4.18 (1.68 to 10.4)0.0027.72 (2.36 to 25.2)<0.001
eGFR<45+ urine protein (+/−, +, ++)6.70 (2.65 to 17.0)<0.00116.8 (5.04 to 56.1)<0.001
eGFR≥90+ urine protein (+++, ++++)*
90>eGFR≥ 60+ urine protein (+++, ++++)5.02 (1.53 to 16.5)0.0087.43 (1.49 to 37.0)0.014
60>eGFR≥45+ urine protein (+++, ++++)5.71 (1.94 to 16.8)0.00217.0 (4.03 to 71.8)<0.001
eGFR<45+ urine protein (+++, ++++)10.6 (3.43 to 32.68)<0.00155.9 (12.3 to 254)<0.001
  • Adjusted for age, BMI, heart disease history, hypertension history, diabetes mellitus history, smoking, drinking and eGFR decline.

  • *Only three men were in this state, and they were merged into the group of eGFR ≥90+ urine protein (+/−, +, ++) for analysis.

  • eGFR, estimated glomerular filtration rate.