Table 3

OR of having comorbidities for the OA population in the BOA Register compared with the reference cohort

Total study populationHip OAKnee OA
Crude OR
(95% CI)		Adjusted OR
(95% CI)*		Crude OR
(95% CI)		Adjusted OR
(95% CI)*		Crude
(95% CI)		Adjusted OR
(95% CI)*
Individual comorbidities†
 ≥11.62 (1.59 to 1.66)§1.67 (1.63 to 1.71)§1.48 (1.42 to 1.54)§1.53 (1.46 to 1.59)§1.69 (1.65 to 1.74)§1.73 (1.69 to 1.78)§
 ≥21.36 (1.34 to 1.39)§1.41 (1.38 to 1.44)§1.26 (1.22 to 1.30)§1.31 (1.27 to 1.35)§1.41 (1.38 to 1.45)§1.46 (1.43 to 1.49)§
 ≥31.23 (1.21 to 1.26)§1.28 (1.26 to 1.31)§1.14 (1.11 to 1.17)§1.19 (1.16 to 1.23)§1.28 (1.25 to 1.31)§1.33 (1.30 to 1.36)§
Disease categories
 Cancer0.89 (0.86 to 0.92)§0.89 (0.85 to 0.92)§0.90 (0.85 to 0.96)§0.89 (0.84 to 0.95)§0.88 (0.84 to 0.92)§0.88 (0.84 to 0.92)§
 Cardiovascular/blood1.22 (1.20 to 1.24)§1.26 (1.24 to 1.28)§1.15 (1.11 to 1.18)§1.19 (1.15 to 1.23)§1.26 (1.23 to 1.29)§1.29 (1.27 to 1.32)§
 Endocrine1.04 (1.02 to 1.06)§1.09 (1.06 to 1.11)§0.97 (0.93 to 1.01)1.02 (0.98 to 1.06)1.08 (1.05 to 1.10)§1.12 (1.09 to 1.15)§
 Gastrointestinal1.38 (1.35 to 1.40)§1.43 (1.41 to 1.46)§1.31 (1.27 to 1.35)§1.37 (1.33 to 1.42)§1.41 (1.38 to 1.44)§1.46 (1.43 to 1.50)§
 Musculoskeletal/pain-related‡1.03 (1.00 to 1.06)1.04 (1.01 to 1.07)§1.02 (0.97 to 1.07)1.02 (0.97 to 1.08)1.04 (1.00 to 1.07)1.04 (1.01 to 1.08)
 Neurological0.79 (0.76 to 0.82)§0.82 (0.79 to 0.84)§0.74 (0.69 to 0.78)§0.76 (0.71 to 0.80)§0.82 (0.78 to 0.85)§0.84 (0.81 to 0.88)§
 Nutritional/obesity0.92 (0.88 to 0.97)§0.97 (0.92 to 1.02)0.75 (0.68 to 0.83)§0.79 (0.72 to 0.87)§1.01 (0.95 to 1.07)1.06 (0.99 to 1.12)
 Psychological/behavioural0.96 (0.94 to 0.98)§0.99 (0.97 to 1.01)0.94 (0.90 to 0.97)§0.97 (0.93 to 1.00)0.96 (0.94 to 0.99)§1.00 (0.97 to 1.02)
 Renal/urological1.30 (1.26 to 1.34)§1.32 (1.28 to 1.36)§1.24 (1.18 to 1.31)§1.27 (1.20 to 1.34)§1.33 (1.29 to 1.38)§1.34 (1.30 to 1.40)§
 Respiratory1.16 (1.13 to 1.19)§1.18 (1.14 to 1.21)§1.11 (1.06 to 1.16)§1.13 (1.08 to 1.18)§1.18 (1.15 to 1.22)§1.20 (1.16 to 1.24)§
 Miscellaneous1.29 (1.27 to 1.31)§1.29 (1.27 to 1.31)§1.23 (1.19 to 1.27)§1.22 (1.19 to 1.26)§1.32 (1.29 to 1.35)§1.32 (1.29 to 1.35)§

  • *Adjusted for socioeconomic status (educational level, country of birth and marital status).

  • †Individual comorbidities identified by summing the RxRisk Index, the Elixhauser Comorbidity Index and the Charlson Comorbidity Index.

  • ‡The conditions inflammation/pain and pain identified by the RxRisk Index were excluded from the analyses.

  • §Statistically significant results.

  • BOA, Better Management of Patients with Osteoarthritis; OA, osteoarthritis.;