Comorbidities of patients with osteoarthritis (OA) from the BOA Register, compared with the general population
| OA | Ref | RxRisk Index | Elixhauser Comorbidity Index | Charlson Comorbidity Index | ||||
| OA | Ref | OA | Ref | OA | Ref | |||
| Cancer | 6% | 6% | ||||||
| Lymphoma | 0.5% | 0.5% | ||||||
| Malignancies | 0.5% | 0.5% | 5.5% | 6% | ||||
| Metastatic cancer | 0.5% | 1% | 0.5% | 1% | ||||
| Solid tumour without metastasis | 5% | 5.5% | ||||||
| Cardiovascular/blood | 59% | 54% | ||||||
| Anticoagulation agents/coagulopathy | 10% | 9% | 0.5% | 0.5% | ||||
| Antiplatelet agents | 19% | 19% | ||||||
| Arrhythmias | 2% | 2% | 6% | 6% | ||||
| Cerebrovascular disease | 2.5% | 3.5% | ||||||
| Congestive heart failure | 21.5% | 21% | 1.5% | 2.5% | 1.5% | 2.5% | ||
| Hyperlipidaemia | 28% | 26.5% | ||||||
| Hypertension | 31% | 27% | 15% | 14.5% | ||||
| Ischaemic heart disease: angina | 7% | 6.5% | ||||||
| Ischaemic heart disease: hypertension | 34% | 32% | ||||||
| Myocardial infarction | 2.5% | 3% | ||||||
| Peripheral vascular disease | 1% | 1.5% | 1% | 1.5% | ||||
| Pulmonary circulation disorders | 0.5% | 0.5% | ||||||
| Pulmonary hypertension | 0% | 0% | ||||||
| Valvular disease | 1.5% | 1.5% | ||||||
| Endocrine | 19% | 19% | ||||||
| Diabetes (uncomplicated) | 9% | 10% | 4.5% | 5% | 4.5% | 5% | ||
| Diabetes (complicated) | 1.5% | 2% | 1.5% | 2% | ||||
| Hyperthyroidism | 0% | 0% | ||||||
| Hypothyroidism | 10.5% | 9.5% | 2% | 2% | ||||
| Pancreatic insufficiency | 0.5% | 0.5% | ||||||
| Gastrointestinal | 35% | 28% | ||||||
| Gastro-oesophageal reflux disease | 32.5% | 25% | ||||||
| Irritable bowel syndrome | 1.5% | 1% | ||||||
| Liver disease (mild) | 0.5% | 0.5% | 0.5% | 0.5% | ||||
| Liver disease (severe) or failure | 4% | 4.5% | 0% | 0% | ||||
| Peptic ulcer disease | 0.5% | 0.5% | 0.5% | 0.5% | ||||
| Musculoskeletal/pain related | 70% | 45% | ||||||
| - Excluding pain and inflammation/pain | 11% | 10% | ||||||
| Gout | 2.5% | 2.5% | ||||||
| Migraine | 2.5% | 2% | ||||||
| Osteoporosis/Paget’s | 4.5% | 4.5% | ||||||
| Pain | 31.5% | 23% | ||||||
| Inflammation/pain | 58.5% | 31.5% | ||||||
| Rheumatic disease | 1.5% | 2% | ||||||
| Rheumatoid arthritis/collage vascular diseases | 2% | 2.5% | ||||||
| Neurological | 7% | 8% | ||||||
| Dementia | 0% | 1% | 0% | 1% | ||||
| Epilepsy | 4% | 4.5% | ||||||
| Paralysis | 0% | 0.5% | ||||||
| Hemiplegia or paraplegia | 0% | 0.5% | ||||||
| Parkinson’s disease | 2.5% | 2% | ||||||
| Other neurological disorders | 1% | 2% | ||||||
| Nutritional/obesity | 3% | 3% | ||||||
| Blood loss anaemia | 0% | 0% | ||||||
| Deficiency anaemia | 0.5% | 0.5% | ||||||
| Fluid and electrolyte disorders | 0.5% | 1% | ||||||
| Hyperkalaemia | 0% | 0% | ||||||
| Malnutrition | 0% | 0% | ||||||
| Obesity | 2% | 1% | ||||||
| Weight loss | 0% | 0% | ||||||
| Psychological/behavioural | 23% | 24% | ||||||
| Alcohol abuse/dependency | 0.5% | 0.5% | 0.5% | 1% | ||||
| Anxiety | 8.5% | 10% | ||||||
| Bipolar disorder | 0.5% | 0.5% | ||||||
| Depression | 17.5% | 17.5% | 2% | 2.5% | ||||
| Drug abuse | 0% | 0.5% | ||||||
| Psychotic illness/psychoses | 0.5% | 1.5% | 0% | 0.5% | ||||
| Smoking cessation | 1.5% | 1.5% | ||||||
| Renal/urological | 9% | 7% | ||||||
| Benign prostatic hyperplasia | 4.5% | 3.5% | ||||||
| Incontinence | 4.5% | 3% | ||||||
| Renal disease/failure | 0.5% | 0.5% | 0.5% | 1% | 0.5% | 1% | ||
| Respiratory | 12% | 11% | ||||||
| Chronic pulmonary disease | 3% | 3.5% | 3% | 3.5% | ||||
| Chronic airways disease | 11% | 9.5% | ||||||
| Miscellaneous | 37% | 31% | ||||||
| Allergies | 24% | 19.5% | ||||||
| Glaucoma | 4% | 4% | ||||||
| HIV/AIDS | 0% | 0% | 0% | 0% | 0% | 0% | ||
| Psoriasis | 1.5% | 1.5% | ||||||
| Steroid-responsive conditions | 16.5% | 13.5% | ||||||
| Transplant | 0% | 0% | ||||||
Comorbidities presented as disease categories and as individual comorbidities, identified by the RxRisk Index, the Elixhauser Comorbidity Index and the Charlson Comorbidity Index, for the OA population (n=72 069) compared with their references from the general population (n=216 207). All numbers are reported as percentages (%). The numbers marked in bold are the percentage of each population that has been identified with at least one of the individual diseases included in that disease category. The other numbers are the percentage of each population that has been identified with each individual disease by each of the indices.
BOA, Better Management of Patients with Osteoarthritis.