Study name | Study site selection rationale and period | Goal | Extra resources provided to hospitals (H) by projects* | Extra notes |
RTS, S/AS01 trial: (ClinicalTrials.gov Identifier: NCT03806465) | Study start: December 2018 Site selection: by MoH/WHO, selecting high volume public hospitals in regions getting the vaccine. | The evaluation of the feasibility, safety and impact of the RTS, S/AS01 malaria vaccine in paediatric cases in Kenya | One extra healthcare worker provided per paediatric ward. Extra pulse oximetry equipment provided per ward:
| Clinician role: promote compliance with guidelines for meningitis and malaria including complete assessment and investigations including the performance of lumbar punctures, and consenting participants for storage of cerebrospinal fluid storage |
SEARCH trial (ClinicalTrials.gov Identifier: NCT04041791) | Started in two phases:
Site selection: from the expected size of pneumonia population, the geographical balance of hospitals and support from local hospital teams | Pragmatic factorial individually randomised controlled trial to compare alternative antibiotics and alternative modes of fluid therapy for children with severe pneumonia | One extra healthcare worker provided per participating hospital. Extra pulse oximetry equipment provided to the hospital:
| Clinician role: promote compliance with the study protocol, including completing patient assessment, investigations and diagnoses. Ensure appropriate administration of study interventions. Recruitment of study participants was suspended on the 8 April 2020 due to COVID-19 pandemic. Adult inpatient surveillance in addition to paediatric surveillance began on the 4 May 2020. |
H15 got one pulse oximeter in June 2020 even though it was not part of any study.
*We were not able to track and record introduction of pulse oximeters procured directly by hospitals or other sources, or those personally owned by healthcare workers, nor ability to repair existing pulse oximeters when required.
MoH, Ministry of Health.