Comparison of treatment groups for secondary outcomes (intention-to-treat population using available cases)
| Usual care | Home-based rehab | Adjusted difference (95% CI) | P value | ||||
| Mean (SD) | Total | Mean (SD) | Total | ||||
| LLFDI disability (frequency) | Baseline | 51.28 (7.25) | 311 | 51.55 (7.46) | 308 | – | – |
| 6 months | 54.27 (6.86) | 283 | 54.91 (6.85) | 275 | 0.64 (–0.50 to 1.78) | 0.27 | |
| 12 months | 54.13 (6.87) | 287 | 55.05 (6.87) | 279 | 0.93 (–0.21 to 2.06) | 0.11 | |
| LLFDI disability (limitation) | Baseline | 66.26 (11.96) | 312 | 66.25 (12.48) | 305 | – | – |
| 6 months | 72.33 (15.25) | 284 | 74.72 (15.24) | 275 | 2.39 (–0.14 to 4.92) | 0.06 | |
| 12 months | 74.10 (15.27) | 287 | 74.75 (15.28) | 277 | 0.65 (–1.87 to 3.18) | 0.61 | |
| OKS | Baseline | 20.59 (7.50) | 312 | 20.81 (7.31) | 308 | – | – |
| 6 months | 35.69 (7.69) | 284 | 36.23 (7.69) | 277 | 0.540.73 to 1.81) | 0.40 | |
| 12 months | 37.34 (7.71) | 287 | 37.80 (7.71) | 278 | 0.46 (–0.81 to 1.73) | 0.48 | |
| KOOS – QoL subscale | Baseline | 25.50 (16.58) | 301 | 25.50 (15.89) | 300 | – | – |
| 6 months | 61.26 (22.31) | 273 | 62.47 (22.29) | 269 | 1.21 (–2.55 to 4.97) | 0.53 | |
| 12 months | 65.53 (22.37) | 277 | 65.26 (22.36) | 271 | −0.27 (–4.02 to 3.47) | 0.89 | |
| PASE | Baseline | 121.24 (73.90) | 302 | 115.11 (72.95) | 297 | – | – |
| 6 months | 150.62 (66.72) | 259 | 149.41 (66.46) | 245 | −1.22 (–12.86 to 10.42) | 0.84 | |
| 12 months | 156.58 (66.82) | 263 | 154.63 (66.73) | 251 | −1.95 (–13.51 to 9.61) | 0.74 | |
| EQ5D-5L utility | Baseline | 0.52 (0.22) | 308 | 0.52 (0.23) | 308 | – | – |
| 6 months | 0.75 (0.18) | 277 | 0.75 (0.18) | 275 | 0.00 (–0.03 to 0.03) | 0.85 | |
| 12 months | 0.76 (0.18) | 282 | 0.76 (0.18) | 278 | −0.00 (–0.03 to 0.03) | 0.99 | |
| EQ5D-5L VAS | Baseline | 68.53 (19.46) | 312 | 68.03 (19.13) | 308 | – | – |
| 6 months | 75.81 (14.55) | 283 | 75.51 (14.54) | 275 | −0.30 (–2.71 to 2.11) | 0.81 | |
| 12 months | 76.80 (14.57) | 287 | 77.05 (14.58) | 278 | 0.24 (–2.16 to 2.65) | 0.84 | |
Totals refer to the total number of participants in each group that provided each score at each time point. Adjusted differences were calculated using linear mixed effects models adjusted for stratification factors and baseline scores.
Each LLFDI disability scale ranges from 0 to 100 with higher scores indicating less disability.
Scores range from 0 to 48 with higher scores indicating better knee function.
Scores range from 0 to 100 with higher scores indicating better QoL. PASE, higher scores indicate greater levels of physical activity.
EQ5D-5L utility scores range from −0.594 to 1 and EQ5D-5L VAS ranges from 0 to 100, in both cases higher scores indicate better QoL.
KOOS, Knee injury and Osteoarthritis Outcome Score; LLFDI, Late-Life Function and Disability Instrument; OKS, Oxford Knee Score; PASE, Physical Activity Scale for the Elderly; QoL, quality of life; VAS, Visual Analogue Scale.