Table 1

Definitions of alarm symptoms for IBD

Alarm symptomMethod of ascertainmentDefinition of positive finding
Positive family history for IBDHistoryAffected first-degree relative(s)
Rectal bleedingHistory
Involuntary weight lossHistory +physical examination
Decreased growth velocityHistory +physical examination
Aphthous stomatitisHistory +physical examination
ArthritisHistory +physical examination
Eye inflammationHistory +physical examinationUveitis, (epi) scleritis
Skin abnormalitiesPhysical examinationPyoderma gangrenosum, psoriasis, erythema nodosum
Perianal abnormalitiesPhysical examinationSkin tags, perianal fistulas, haemorrhoids, perianal fissures, perianal abscesses
  • These definitions apply to the alarm symptoms mentioned in the protocol, figures and online supplemental files.

  • IBD, inflammatory bowel disease.