Table 3

Reporting adverse events, COI and funding before and after consort 2001 by included studies (N=237 and 195, respectively)

ReportingStudies up to 2001 (inclusive)
(n=237)
Studies from 2002 (inclusive)
(n=195)
Significance of difference
N%N%
Adverse events reportingDrug-related adverse events reported (other than death/antibiotic resistance)
Yes1466212162
No*91387438p=0.92
Deaths reported
Yes45194222
No*1928115378p=0.51
Antibiotic resistance reported
Yes93396533
No1446113067p=0.21
COICOI statement provided?
Yes5210755
No232988845p<0.001
COI present?
Present102714
Absent428041
Unclear (no COI statement provided)232988845p<0.001
FundingFunding statement provided?
Yes1466213670
No91385930p=0.077
  • *Trials whose reporting of adverse events was unclear were included in the ‘not reported’ category

  • COI, conflict of interest.