Table 1

Inclusion and exclusion criteria for recruitment

Section 1—inclusion criteriaSection 1—exclusion criteriaSection 2—inclusion criteriaSection 2—exclusion criteria
Patients between the ages of 1–16 years old, should the patient be cooperative enough to tolerate testingPatient has significant comorbid disease which could significantly influence visual electrophysiology interpretation, outside of that expected for raised ICP (ie, significant retinal dysfunction).Patients between the ages of 1 and 16 years, who are undergoing ICP monitoring within GOSHPatient has comorbid disease which may affect study findings
For disease group: a diagnosis of IIH, hydrocephalus or craniosynostosisPatient is unable to tolerate electrophysiological tests±patient is poorly cooperative causing poor quality or unreliable data setsPatient able to tolerate standard clinical assessments and PhNR measurements
For the control group: patients with otherwise normal visual electrophysiology and no objective evidence of retinal or optic nerve disease or condition known to cause rICPPatient has symptomatic cause for raised ICP which could confound test findings (ie, frontal lobe meningioma or other space occupying lesions affecting the visual pathway)Participants consent to serial recording of PhNR
Fundus imaging or OCT performed as per standard practicePatient is on sedative or other medication which has a potential but unknown effect on the PhNR component of the ERG.Patient is alert or in natural sleep for testing during ICP monitoring period
Patient must be referred for visual electrophysiology testing as per standard practice (ie, recruited participants will only be those standardly referred to this service to maintain standard practice)Other causes for rICP will be included, so long as they do not knowingly affect the visual pathways
  • ERG, electroretinogram; GOSH, Great Ormond Street Hospital; ICP, intracranial pressure; IIH, idiopathic intracranial hypertension; OCT, optical coherence tomography; PhNR, photopic negative response; rICP, raised intracranial pressure.