Table 2

Reporting of adverse events, COI and funding by the included RCTs (N=432)

Any type of adverse eventAll trials
Reported (n=334)Not reported (n=98)(n=432)
N%N%N%
Adverse events reportingDrug-related adverse events reported (other than death / antibiotic resistance)
Yes2668026662
No*441314233
Unclear247245
Deaths reported
Yes87268720
No2477434580
Antibiotic-resistance reported
Yes1584715836.6
No1735227162.7
Unclear3130.70%
COICOI statement provided?
Yes9027222211226
No24473767832074
COI present?
Present24744287
Absent662018188419
Unclear (no COI statement provided)24473767832074
FundingFunding statement provided?
Yes23169525328366
No10331464714934
Was the study funded?
Yes22166505127163
No10322123
Unclear (no funding statement provided)10331464714934
Source of funding?†, ‡
Industry10045173411743
Non-industry663018368431
Both (industry and non-industry)542515306926
Statement about the funder’s role provided?§
Industry
Yes
No53535295850
Non-industry474712715950
Yes
No19292112125
Both (industry and non-industry)477116896375
Yes438010675377
No11205331633
  • *Funding body involvement included, but not limited to, drug supply, laboratory services, study co-ordination and monitoring.

  • †The denominator here is for the number funded studies per each group.

  • ‡The source of funding was not clear for one study

  • §The denominator here is for the total number of studies per each source of funding group.

  • COI, conflict of interest; RCT, randomised controlled trial.