Sensitivity analyses examining the relationship between delirium and individual sedation agents prior to first ICDSC assessment
| Sedation agent prior to first ICDSC assessment | Overall cohort | Matched cohorts | |||||
| No of patients | Ever delirium, n (%) | Adjusted OR (95% CI)* | No of patients per group | Ever delirium for propofol patients from matched cohorts, n (%) | Ever delirium, n (%) | Propensity score-matched OR for ever delirium (95% CI)† | |
| Propofol | 887 | 509 (57.4) | 1.00 (reference group) | N/A‡ | N/A‡ | N/A‡ | 1.00 (reference group) |
| Fentanyl | 158 | 91 (57.6) | 1.04 (0.71 to 1.52) | 152 | 74 (48.7) | 87 (57.2) | 1.41 (0.90 to 2.22) |
| Midazolam | 124 | 77 (62.1) | 1.11 (0.73 to 1.69) | 122 | 69 (56.6) | 75 (61.5) | 1.23 (0.74 to 2.05) |
| Propofol+fentanyl | 854 | 543 (63.6) | 1.32 (1.06 to 1.65) | 565 | 323 (57.2) | 347 (61.4) | 1.19 (0.94 to 1.51) |
| Propofol+midazolam | 224 | 163 (72.8) | 1.72 (1.23 to 2.43) | 223 | 143 (64.1) | 162 (72.6) | 1.49 (1.00 to 2.23) |
| Fentanyl+midazolam | 222 | 160 (72.1) | 1.72 (1.22 to 2.46) | 214 | 119 (55.6) | 153 (71.5) | 2.00 (1.34 to 3.00) |
| All 3 | 368 | 269 (73.1) | 1.84 (1.38 to 2.47) | 335 | 199 (59.4) | 241 (71.9) | 1.75 (1.27 to 2.42) |
ICDSC, Intensive Care Delirium Screening Checklist; NA, not available.