Table 1

Baseline characteristics

Overall cohortDominant sedation strategy matched cohorts
Propofol
(n=1412)
Fentanyl
(n=1069)
Midazolam
(n=356)
Propofol versus midazolam matched cohortPropofol versus fentanyl matched cohort
Propofol
(n=356)
Midazolam
(n=356)
Propofol
(n=866)
Fentanyl
(n=866)
Characteristic
Age, median (IQR)56 (42–67)59 (44–69)59 (46–71)58 (48–69)59 (46–71)57 (46–68)57 (42–69)
Male, n (%)843 (59.7)656 (61.4)223 (62.6)227 (63.8)223 (62.6)533 (61.5)520 (60.0)
Admission reason, n (%)
 Medical791 (56.0)379 (35.5)259 (72.8)253 (71.1)259 (72.8)426 (49.2)379 (43.8)
 Surgical265 (18.8)405 (37.9)69 (19.4)74 (20.8)69 (19.4)256 (29.6)248 (28.6)
 Neurological245 (17.4)73 (6.8)19 (5.3)18 (5.1)19 (5.3)76 (8.8)73 (8.4)
 Trauma109 (7.7)211 (19.7)9 (2.5)11 (3.1)9 (2.5)108 (12.5)166 (19.2)
Location admitted from
 Emergency room833 (59.0%)413 (38.6%)190 (53.4%)202 (56.7)190 (53.4)441 (50.9)369 (42.6)
 Operating room/recovery278 (19.7%)399 (37.3%)59 (16.6%)63 (17.7)59 (16.6)232 (26.8)271 (31.3)
 Hospital ward254 (18.0%)209 (19.6%)91 (25.6%)85 (23.9)91 (25.6)165 (19.1)180 (20.8)
 Another hospital26 (1.8%)24 (2.2%)7 (2.0%)4 (1.1)7 (2.0)17 (2.0)23 (2.7)
 Other21 (1.5%)24 (2.2%)9 (2.5%)2 (0.6)9 (2.5)11 (1.3)23 (2.7)
Charlson Score, n (%)
 0582 (41.2%)422 (39.5%)121 (34.0%)127 (35.7)121 (34.0)322 (37.2)336 (38.8)
 1317 (22.5%)239 (22.4%)70 (19.7%)61 (17.1)70 (19.7)201 (23.2)207 (23.9)
 2+513 (36.3%)408 (38.2%)165 (46.3%)168 (47.2)165 (46.3)343 (39.6)323 (37.3)
Charlson Score, median (IQR)1 (0–2)1 (0–2)1 (0–3)1 (0–3)1 (0–3)1 (0–3)1 (0–2)
Admission SOFA score, median (IQR)6 (4–8)7 (5–10)8 (6–11)8 (5–10)8 (6–11)7 (4–9)7 (4–10)
Admission APACHE II score, median (IQR)18 (13–24)19 (14–25)23 (16–28)21 (16–27)23 (16–28)19 (14–24)19 (13–26)
Vasoactive medications, n (%)639 (45.3%)690 (64.5%)245 (68.8%)241 (67.7)245 (68.8)526 (60.7)488 (56.4)
Continuous renal replacement therapy, n (%)59 (4.2%)78 (7.3%)33 (9.3%)28 (7.9)33 (9.3)52 (6.0)73 (8.4)