Table 4

Sensitivity analyses based on those on a single sedation strategy or those whose sedation strategy was dominant for ≥6 hours over the other two strategies

OutcomeDominant sedation strategyPropensity score-matched OR, mean ratio or rate ratio (95% CI)*
Delirium everPropofol1.00 (reference group)
Fentanyl (n=476)1.29 (0.99 to 1.69)
Midazolam (n=231)1.64 (1.12 to 2.41)
Delirium or ICU deathPropofol1.00 (reference group)
Fentanyl (n=476)1.38 (1.05 to 1.81)
Midazolam (n=231)1.75 (1.18 to 2.60)
ICU mortalityPropofol1.00 (reference group)
Fentanyl (n=476)1.82 (1.18 to 2.84)
Midazolam (n=231)1.31 (0.73 to 2.39)
Hospital mortalityPropofol1.00 (reference group)
Fentanyl (n=476)1.69 (1.19 to 2.42)
Midazolam (n=231)1.50 (0.92 to 2.49)
Died within 30 days of ICU admissionPropofol1.00 (reference group)
Fentanyl (n=476)1.84 (1.27 to 2.68)
Midazolam (n=231)1.14 (0.69 to 1.89)
Died within 1 year of ICU admissionPropofol1.00 (reference group)
Fentanyl (n=476)1.38 (1.02 to 1.86)
Midazolam (n=231)1.16 (0.77 to 1.76)
Died within 1.5 years of ICU admissionPropofol1.00 (reference group)
Fentanyl (n=476)1.25 (0.94 to 1.66)
Midazolam (n=231)1.25 (0.84 to 1.85)
ICU length of stay, mean ratio (95% CI)Propofol1.00 (reference group)
Fentanyl (n=476)1.23 (1.09 to 1.39)
Midazolam (n=231)1.01 (0.86 to 1.20)
Hospital length of stay, mean ratio (95% CI)Propofol1.00 (reference group)
Fentanyl (n=476)1.31 (1.13 to 1.51)
Midazolam (n=231)1.01 (0.83 to 1.22)
Duration of invasive ventilation, mean ratio (95% CI)Propofol1.00 (reference group)
Fentanyl (n=476)1.35 (1.14 to 1.59)
Midazolam (n=231)1.17 (0.94 to 1.46)
No of delirium days, rate ratio (95% CI)Propofol1.00 (reference group)
Fentanyl (n=476)1.19 (0.99 to 1.43)
Midazolam (n=231)1.11 (0.85 to 1.44)
  • Bold values demonstrate a statistically signficant result.

  • *Data presented as ORs unless otherwise indicated.

  • ICU, intensive care unit.