Table 2

Discrepancies in Number of Outcomes Reported (N=67 studies)

Type of discrepancyNumber (%) of studies with at least one outcome that was reported only in the preprint or journal publication (n=67)Number and description of outcomes across all studies that were reported only in the preprint or journal publication
Outcome reported in journal publication only15 (22%)N=19 (numbering indicates unique studies, lettering indicates outcomes from the same study)
(1a) Treatment-associated toxicities
(1b) Adverse reactions
(2) Survival at intensive care unit (ICU) discharge
(3) Creatine phosphokinase
(4) Radiographic scale for acute respiratory distress syndrome
(5) Time to negative swab
(6) Time to reverse transcription-PCR negativity
(7) Clinical outcomes at discharge
(8) Ventilator status of those remaining hospitalised at end of follow-up
(9a) Secondary composite—cardiovascular complications
(9b) Acute renal failure
(10) Creatinine phosphokinase
(11) Sequential organ failure assessment score
(12) Length of stay
(13) WHO Clinical Progression Scale
(14a) sCD14 levels related to corticoid treatment
(14b) Hospital Stay
(14c) Onset of symptoms
(15) Mechanical ventilation or all-cause mortality at 21 days
Outcome reported in preprint only8 (12%)N=17 (numbering indicates unique studies, lettering indicates outcomes from the same study)
(1a) Oxygen support need
(1b) Invasive mechanical ventilation need
(1c) ICU need
(1d) Need for inotropics
(1e) Naso/oropharyngeal swab viral clearance
(2a) Final lymphocyte (cell/mm3)
(2b) Final C reactive protein (CRP) (mg/L)
(3a) Negative conversion of SARS-CoV-2 by 28 days
(3b) Negative conversion rate at 4-day, 7-day, 10-day, 14-day or 21-day
(3c) Changes of CRP values and blood lymphocyte count
(3d) Rate of symptoms alleviation within 28-day
(3e) Safety endpoints
(4) QTc ≥470 ms
(5) Cumulative virus clearance rate vs different antiviral regimes in (a) all patients and (b) patients with moderate illness
(6) Adverse events
(7) Composite cardiovascular and renal failure
(8) Nosocomial infections