Variables used to calculate time under observation for each participant
| Source | Variable name |
| CSR22–24 | Last day in study |
| CSR25 26 | Observation day |
| IPD | aestartday |
| IPD | aeendday |
| IPD | pain_d01 pain_d02 … pain_d98 |
| IPD20–25 27 | sleep_d01 sleep_d02 … sleep_d98 |
| CSR20 21 | Study day last double-blind medication |
| CSR25 26 | Day of last dose of study drug |
CSR, clinical study report; IPD, individual participant data.