Table 2

Treatment-related grade 3–5 toxicities

Toxicity typeGrade 3 (%)Grade 4 (%)Grade 5 (%)
Haematological
 Anaemia14 (5)00
 Neutropenia18 (7)8 (3)0
 Thrombocytopenia6 (2)1 (0.4)0
 Febrile neutropenia12 (4)2 (0.7)3 (1)
 Cumulative haematological46 (17)11 (4)3 (1)
Non-haematological
 Diarrhoea16 (6)4 (2)3 (1)*
 Vomiting12 (4)1 (0.4)1 (0.3)†
 Mucositis10 (4)0
 Constipation1 (0.4)0
 Hand-foot-syndrome1 (0.4)
 Neuropathy3 (1)
 Infection with normal ANC47 (17)7 (3)
 Hyponatremia8 (3)2 (0.7)
 Fatigue24 (9)
 Sudden cardiac death4 (1)
 Cumulative non-haematological99(37)13(5)8 (3)
 Cumulative (all toxicities)119(44)22(8)11 (4)
  • *All three patients developed dehydration with resulting acute renal failure.

  • †Patient developed grade 4 vomiting with irreversible grade 4 hyponatremia resulting in death.

  • ANC, Absolute neutrophil count.