Instrument for data collection | |
Primary outcome | |
Quality of life—Physical Component Summary | SF-36 |
Secondary outcomes | |
Strength measures | |
Leg power | Power rig |
Handgrip strength | Handheld dynamometer |
Functional capacity | |
Muscle endurance | Functional Index 3 test |
Combined function | 30 s chair rise test |
Combined function | Timed up-and-go test |
Gait function | 2-min walk test |
Balance | SPPB—balance part |
Body composition | |
Whole-body, appendicular (arms and legs) and lower-limb lean mass | Dual-energy X-ray absorptiometry |
Fat-free mass, body fat and total mass | Bioimpedance |
Disease activity | |
Physician Global Activity | VAS score (1–10) |
Patient Global Activity | VAS score (1–10) |
Extra-muscular Disease Activity | VAS score (1–10) |
Muscle strength | Manual muscle test 8 |
Self-perceived physical functions | Health Assessment Questionnaire |
Creatine kinase | Blood test analysis |
Disease damage | |
Physician global assessment of disease damage | VAS score (1–10) |
Patient global assessment of disease damage | VAS score (1–10) |
Questionnaires | |
Basic cardiovascular questionnaire concerning medical conditions, current medication, heart symptoms and smoking habits | |
Self-reported levels of physical activity | IPAQ-long |
Quality of life—The Mental Health Component Summary | SF-36 |
Cardiovascular comorbidities | |
Body mass index | Height/weight measures |
Systolic and diastolic blood pressure | Sphygmomanometer |
Lipid profile, HbA1c, troponins, NT-proBNP | Blood test analysis |
ECG | ECG machine |
Explorative outcomes | |
Muscle biopsy analysis | Immunohistochemistry |
HbA1c, glycated haemoglobin; IPAQ-long, International Physical Activity Questionnaire - long; NT-proBNP, N-terminal pro b-type Natriuretic Peptide; SF-36, Short Form-36 health questionnaire; SPPB, Short Physical Performance Battery; VAS, Visual Analogue Scale.