Selection of BASE-II follow-up characteristics as assessed of theGendAge study
| Total number of observations | Women* (N=573, 52.1%) | Men* (N=527, 47.9%) | P value† | |
| Age (years) | 1100 | 75.7 (±3.5) | 75.5 (±4.0) | 0.276 |
| Highest school degree | ||||
| Elementary school | 1095 | 35 (6.1%) | 18 (3.4%) | <0.001 |
| Intermediate school | 183 (32.0%) | 104 (19.9%) | ||
| High school | 354 (61.9%) | 401 (76.7%) | ||
| Family status | ||||
| Married | 1098 | 218 (38.0%) | 386 (73.5%) | <0.001 |
| Not married, in partnership | 12 (2.1%) | 19 (3.6%) | ||
| Single | 60 (10.5%) | 33 (6.3%) | ||
| Divorced | 187 (32.6) | 51 (9.7%) | ||
| Widowed | 89 (15.5%) | 26 (5.0%) | ||
| Other | 7 (1.2%) | 10 (1.9) | ||
| Employment status | ||||
| Retired | 1055 | 540 (97.6) | 486 (96.8) | 0.689 |
| Self-rated health | ||||
| Very good | 1096 | 56 (9.8%) | 65 (12.4%) | 0.499 |
| Good | 284 (49.7%) | 262 (50.0%) | ||
| Fair | 166 (29.0%) | 143 (27.3%) | ||
| Poor or very poor | 66 (11.5%) | 54 (10.3%) | ||
| Satisfaction with life in general | 1097 | 7.9 (±1.6) | 8.1 (±1.4) | <0.05 |
| Digit Symbol Substitution Test‡ | 1095 | 41.37 (±8.48) | 39.21 (±9.67) | <0.001 |
| Verbal learning test | 925 | 41.6 (±12.3) | 44.0 (±12.8) | <0.01 |
| Depression (ever diagnosed) | 1095 | 122 (21.3%) | 63 (12.0%) | <0.001 |
| BMI | 1098 | 26.6 (±4.7) | 27.4 (±3.7) | <0.01 |
| Physical inactive§ | 1096 | 67 (11.7%) | 65 (12.4%) | 0.781 |
| Diabetes mellitus type II (self-reported) | 1097 | 49 (8.6%) | 82 (15.6%) | <0.001 |
| Diabetes mellitus type II (diagnosed/ American Diabetes Association guidelines 2019) | 1097 | 76 (13.3%) | 109 (20.7%) | <0.01 |
| Metabolic syndrome (diagnosed, American Heart Association/ International Diabetes Federation/ National Heart, Lung,and Blood Institute criteria 2009) | 1074 | 252 (45.5%) | 327 (62.9%) | <0.001 |
| Hypertension | 1097 | 296 (51.7%) | 311 (59.2%) | <0.05 |
| Myocardial infarction | 1097 | 11 (1.9%) | 24 (4.6%) | <0.05 |
| Stroke | 1096 | 13 (2.3%) | 20 (3.8%) | 0.158 |
| Peripheral artery disease | 1094 | 8 (1.4%) | 15 (2.9%) | 0.138 |
| Morbidity index | 955 | 1.0 (IQR 2.0) | 1.0 (IQR 2.0) | 0.981 |
| Pulse wave velocity (m/s) | 932 | 11.21 (±0.92) | 11.04 (±0.91) | <0.01 |
| Left ventricular ejection fraction (%) | 773 | 64.12 (±6.24) | 62.92 (±5.76) | <0.01 |
| Left ventricular mass (g) | 691 | 135.24 (±31.87) | 179.76 (±38.96) | <0.001 |
| Left ventricular mass index (g)¶ | 690 | 78.55 (±16.83) | 91.22 (±17.96) | <0.001 |
| Left ventricular end-diastolic volume (mL)¶ | 773 | 54.10 (±12.24) | 63.67 (±13.58) | <0.001 |
| Frailty (Fried) | ||||
| Not frail | 1087 | 260 (45.4%) | 251 (47.6%) | 0.542 |
| Pre-frail | 280 (48.9%) | 248 (47.1%) | ||
| Frail | 28 (4.9%) | 20 (3.8%) | ||
| Maximal hand grip strength (kg) | 1098 | 20.5 (±4.4) | 35.1 (±6.8) | <0.001 |
| Recent thymic emigrants (naïve CD4+ T cells) | 395** | 64.69 (±16.34) | 51.03 (±13.69) | <0.001 |
| TEMRA (effector memory T cells re-expressing CD45RA) | 395** | 32.82 (±19.96) | 34.94 (±21.29) | 0.309 |
| Cytotoxic SLAMF7+CD4+ T cells | 181†† | 6.02 (±5.98) | 6.05 (±6.60) | 0.974 |
*Data are presented as N (%), mean±SD or median (IQR).
†Differences between women and men were assessed using the parametric t-test, the non-parametric Mann-Whitney U test or the χ2 where appropriate.
‡Assessed at study visit 1.
§Assessed with the question, ‘Are you seldom or never physically active?’.
¶Adjusted for body surface area.
**845 expected to be available after completion of the analyses.
††629 expected to be available after completion of the analyses.
BMI, body mass index.