History | Event/total (weighted %) | Unadjusted OR (95% CI) | P value | Model 1 OR (95% CI) | P value | Model 2 OR (95% CI) | P value | Model 3 OR (95% CI) | P value |
Any | 528/2916 (18.1) | 1.310 (1.122 to 1.531) | 0.001 | 1.562 (1.290 to 1.891) | <0.001 | 1.350 (0.815 to 2.238) | 0.244 | 1.356 (0.805 to 2.284) | 0.252 |
<1 month | 21/203 (10.3) | 0.680 (0.426 to 1.086) | 0.107 | 0.898 (0.540 to 1.494) | 0.680 | 0.492 (0.170 to 1.419) | 0.189 | 0.506 (0.196 to 1.474) | 0.212 |
1 month–1 year | 145/835 (17.4) | 1.239 (0.996 to 1.540) | 0.054 | 1.677 (1.303 to 2.160) | <0.001 | 1.025 (0.535 to 1.966) | 0.940 | 1.011 (0.507 to 1.963) | 0.974 |
1–2 years | 52/320 (16.3) | 1.144 (0.829 to 1.578) | 0.414 | 1.411 (0.987 to 2.017) | 0.059 | 1.640 (0.564 to 4.767) | 0.364 | 1.694 (0.511 to 5.066) | 0.346 |
2–10 years | 219/1190 (18.4) | 1.329 (1.097 to 1.611) | 0.004 | 1.540 (1.227 to 1.933) | <0.001 | 1.318 (0.720 to 2.413) | 0.371 | 1.306 (0.631 to 2.446) | 0.404 |
>10 years | 91/368 (24.7) | 1.936 (1.482 to 2.530) | <0.001 | 1.926 (1.426 to 2.600) | <0.001 | 4.861 (1.785 to 13.241) | 0.002 | 4.717 (1.721 to 12.926) | 0.003 |
Model 1: model adjusting for demographic covariables including age, race and education.
Model 2: model adjusting for individual covariables including body mass index, smoking status, alcohol use, history of thyroid disease, current thyroid disease and all variables in model 1.
Model 3: model adjusting for gynaecological covariables including first menstrual age, pregnancy history, menopause status, history of hormone replacement use and all variables in model 2.