Association between specific and total number of comorbidities with achieving a Patient Acceptable Symptom State (PASS) 12 months after total knee arthroplasty
| Independent variable | Dependent variable | |
| Patient Acceptable Symptom State ‘acceptable’ 12 months post-TKA | ||
| Unadjusted OR (95% CI) | Adjusted OR (95% CI)* | |
| Primary model: Specific comorbid conditions | ||
| Heart disease | 1.67 (0.78 to 3.49) | 1.27 (0.54 to 3.02) |
| Lung disease | 0.72 (0.23 to 1.35) | 0.78 (0.34 to 1.82) |
| Diabetes | 0.71 (0.50 to 1.01) | 0.64 (0.44 to 0.94) |
| Cancer | 1.46 (0.68 to 3.17) | 1.04 (0.38 to 2.88) |
| Back pain | 0.82 (0.54 to 1.23) | 1.00 (0.63 to 1.59) |
| Gastrointestinal disease | 1.56 (0.77 to 3.18) | 2.19 (0.89 to 5.39) |
| Anaemia/ haematological disease | 1.27 (0.35 to 4.70) | 1.26 (0.36 to 4.35) |
| Other painful/disabling disorders† | 0.39 (0.17 to 0.92) | 0.65 (0.23 to 1.84) |
| Total number troublesome joints to per joint | 0.84 (0.75 to 0.94) | 0.85 (0.76 to 0.96) |
| Depressed mood‡ | 0.58 (0.35 to 0.95) | 0.70 (0.41 to 1.19) |
| n=901 QIC 667.09 | ||
| Secondary model: Number of comorbid conditions (ref=0)§ | ||
| 1 | 0.54 (0.25 to 1.15) | 0.52 (0.24 to 1.13) |
| 2 | 0.57 (0.28 to 1.15) | 0.57 (0.28 to 1.16) |
| ≥3 | 0.51 (0.24 to 1.08) | 0.53 (0.24 to 1.18) |
| n=985 QIC 723.03 | ||
*Models adjusted for age, sex, education, smoking status and social support, as well as clustering by surgeon.
†Other painful disorder defined as fibromyalgia, migraines and/or neurological disease.
‡Depressed mood defined as PHQ-8 score ≥10.
§Total number of conditions include 12 conditions assessed (did not include obesity or total number of troublesome joints, but included kidney disease, liver disease and hypertension that were not included as specific conditions); obesity and troublesome joints included separately in model.
PHQ, Patient Health Questionnaire Depression Scale; QIC, quasi-information criteria; TKA, total knee arthroplasty.