Univariate and multivariate Cox proportional regression analyses of all-cause mortality in the overall cohort
| Univariate analysis | Multivariate analysis | |||
| HR (95% CI) | P value | Adjusted HR (95% CI) | P value | |
| Men | 1.30 (1.18 to 1.42) | <0.01 | 1.40 (1.25 to 1.57) | <0.01 |
| Age | 1.01 (0.99 to 1.03) | 0.13 | 0.99 (0.97 to 1.01) | 0.31 |
| Clinical Frailty Scale 1–3 | 0.77 (0.70 to 0.85) | <0.01 | 0.81 (0.73 to 0.90) | <0.01 |
| NYHA class 3 or 4 | 1.33 (1.21 to 1.46) | <0.01 | 1.18 (1.07 to 1.31) | <0.01 |
| Smoking | 1.20 (1.08 to 1.33) | <0.01 | 1.02 (0.90 to 1.15) | 0.74 |
| Diabetes mellitus | 1.12 (1.00 to 1.24) | 0.04 | 0.99 (0.89 to 1.11) | 0.87 |
| Hypertension | 0.97 (0.88 to 1.09) | 0.63 | 0.97 (0.86 to 1.08) | 0.54 |
| Previous myocardial infarction | 1.32 (1.13 to 1.52) | <0.01 | 1.14 (0.96 to 1.35) | 0.14 |
| Previous coronary artery bypass grafting | 1.21 (1.02 to 1.40) | 0.03 | 1.05 (0.88 to 1.24) | 0.60 |
| Peripheral artery disease | 1.35 (1.21 to 1.50) | <0.01 | 1.08 (0.95 to 1.22) | 0.24 |
| Previous stroke | 1.14 (0.99 to 1.30) | 0.06 | 1.04 (0.90 to 1.19) | 0.62 |
| Atrial fibrillation | 1.19 (1.07 to 1.32) | <0.01 | 1.00 (0.90 to 1.12) | 0.98 |
| STS risk score | 1.04 (1.03 to 1.04) | <0.01 | 1.02 (1.01 to 1.03) | <0.01 |
| eGFR, mL/min/1.73 m2 | 0.98 (0.98 to 0.99) | <0.01 | 0.99 (0.99 to 1.00) | <0.01 |
| Haemoglobin, g/L | 0.83 (0.78 to 0.88) | <0.01 | 0.85 (0.80 to 0.91) | <0.01 |
| Medication at admission | ||||
| Statin | 0.84 (0.77 to 0.93) | <0.01 | 0.86 (0.77 to 0.95) | <0.01 |
| Renin-angiotensin inhibitor | 0.92 (0.84 to 1.01) | 0.08 | 0.88 (0.80 to 0.97) | 0.01 |
| ß blocker | 1.09 (0.99 to 1.20) | 0.08 | 1.06 (0.96 to 1.16) | 0.28 |
| Preprocedural echocardiographic data | ||||
| Aortic valve area, cm2/m2 | 1.29 (0.76 to 2.20) | 0.35 | 1.23 (0.63 to 2.38) | 0.54 |
| Peak velocity, mm Hg | 0.75 (0.67 to 0.85) | <0.01 | 0.76 (0.66 to 0.88) | <0.01 |
| Ejection fraction, % | 0.99 (0.98 to 0.99) | 0.03 | 1.01 (1.00 to 1.02) | 0.02 |
| Pulmonary hypertension | 1.50 (1.25 to 1.78) | <0.01 | 1.27 (1.05 to 1.53) | 0.01 |
| Severe aortic regurgitation | 0.56 (0.13 to 1.19) | 0.16 | 0.57 (0.21 to 1.51) | 0.26 |
| Severe mitral regurgitation | 1.34 (0.93 to 1.81) | 0.11 | 0.99 (0.70 to 1.40) | 0.96 |
| Procedural variables | ||||
| Transfemoral approach | 0.81 (0.73 to 0.91) | <0.01 | 0.87 (0.77 to 0.98) | 0.03 |
| Local anaesthesia | 0.89 (0.79 to 1.01) | 0.07 | 0.92 (0.81 to 1.05) | 0.22 |
eGFR, estimated glomerular filtration rate; NYHA, New York Heart Association; STS, Society of Thoracic Surgeons.