Parameter | Base case estimate | Univariable analysis range | Reference(s) |
Complete 9H treatment | $806 | $489–$1207 | IPH, NMH25 |
Drug costs | $5 | ||
DOT costs | $500 | ||
Other clinician costs | $173 | ||
Chest X-ray | $55 | ||
Sputum testing | $64 | ||
Liver function testing | $9 | ||
Partial isoniazid treatment | |||
3 months | $388 | $271–$543 | IPH, NMH25 |
6 months | $597 | $389–$874 | IPH, NMH25 |
Complete 3HP treatment | $383 | $296–$492 | IPH, NMH25 |
Drug costs | $87 | ||
DOT costs | $77 | ||
Other clinician costs | $96 | ||
Chest X-ray | $55 | ||
Sputum testing | $64 | ||
Liver function testing | $5 | ||
Partial isoniazid+rifapentine treatment | |||
4 weeks | $126 | $103–$159 | IPH, NMH25 |
8 weeks | $194 | $151–$253 | IPH, NMH25 |
Mild AE | $13 | $0–$197 | IPH13 |
Nursing costs | $13 | ||
Severe AE | $2584 | $1379–$6614 | IPH, NMH13 25 |
Hospitalisation in Iqaluit×1.2 days* | $2411 | ||
Outpatient clinician assessment | $156 | ||
Laboratory monitoring | $17 | ||
Fatal AEs | $65 737 | $41 365–$75 725 | IPH25 46 |
Hospitalisation in Iqaluit×7 days | $14 059 | ||
Medical evacuation | $19 951 | ||
Hospitalisation in Ottawa x 7 days | $7366 | ||
Intensive care unit in Ottawa×7 days | $24 359 | ||
Cured TB disease | $1517 | $1214–$28 841 | IPH25 |
Fatal TB disease | $66 495 | $41 365–$76 635 | IPH25 46 |
TB treatment costs×6 months | $759 | ||
Hospitalisation in Iqaluit×7 days | $14 059 | ||
Medical evacuation | $19 952 | ||
Hospitalisation in Ottawa×7 days | $7366 | ||
Intensive care unit in Ottawa×7 days | $24 359 | ||
Surveillance for those <13 years old | $54 | $50–$65 | IPH, NMH |
Nursing costs | $54 | ||
Surveillance for those ≥13 years old | $531 | $431–$638 | IPH, NMH |
Nursing costs | $54 | ||
Chest X-ray×4 | $220 | ||
Sputum testing×4 | $257 |
IPH: data from Iqaluit Public Health, 2019, unpublished.
NMH: data from Nunavut Ministry of Health, 2019, unpublished.
*The number of days of hospitalisation was used assuming that, as in Sterling et al, 17% of these patients would have a grade 4 AE and all those with a grade 4 AE would require 7 days of hospitalisation.
AEs, adverse events; DOT, directly observed therapy; 9H, 9 months of twice weekly isoniazid; 3HP, once weekly rifapentine and isoniazid for 12 weeks.