Citation* | Sample size | Population based / random sample | Location | Longitudinal brain health measure | Cognition | MRI brain regions | Diagnosis of cognitive impairment/ dementia |
Brown9 | 249 405 | Yes | USA | No | + | ||
Cherrie63 | 281 | Yes | UK | Yes | +N | ||
Cherrie64 | 281 | Yes | UK | Yes | +N | ||
Clarke53 | 949 | Yes | USA | No | N | ||
Dadvand65 | 2593 | No | Spain | Yes | +N | ||
Dadvand54 | 987 | Yes | Spain | Yes | +N | ||
Dadvand66 | 253 | No | Spain | No | +N | ||
Dzhambov72 | 112 | No | Bulgaria | No | + | +N | |
De Keijzer55 | 6506 | Yes | UK | Yes | +N | ||
Flouri56 | 4758 | Yes | UK | No | + | ||
Hystad57 | 6658 | Yes | Canada | No | - N | ||
Kuhn73 | 341 | No | Germany | No | +N | ||
Liao67 | 1312 | No | China | No | + | ||
Reuben68 | 1658 | Yes | UK | Yes | N | ||
Wang69 | 3544 | No | China | No | N | ||
Ward70 | 72 | No | New Zealand | No | N | ||
Wu59 | 2424 | Yes | UK | No | – | ||
Wu58 | 7505 | Yes | UK | No | - N | ||
Yu71 | 3240 | No | China | No | N | ||
Yuchi60 | 678 000 | Yes | Canada | Yes | + - | ||
Zhu61 | 6994 | Yes | China | Yes | + | ||
Zijlema62 | 1628 | Yes | Spain, UK, Netherlands | No | +N | ||
Studies with positive associations | 9 | 3 | 3 | ||||
Studies with inverse associations | 1 | 0 | 3 | ||||
Studies with null associations | 12 | 3 | 1 | ||||
Total studies | 15 | 3 | 5 |
*Full list of papers found in online supplemental text 1.
+, positive association; -, inverse association; N, null association.