No reduction in LAD (n=275) | Reduction in LAD (n=398) | Between-groups comparison | |||||||||

Variable | Baseline | Follow-up | Delta* | P value (paired) | Baseline | Follow-up | Delta* | P value (paired) | P value (baseline) | P value (follow-up) | P value (delta) |

LAD (mm) | 43.0±8.9 | 46.9±8.8 | 4.0±4.1 | <0.0001 | 46.7±8.0 | 40.8±8.4 | −5.8±4.5 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |

LAD ≥40 mm† | 172/275 (63%) | 227/275 (83%) | 55 (20%) | <0.0001 | 333/398 (84%) | 225/398 (57%) | −108 (−27%) | <0.0001 | <0.0001 | <0.0001 | <0.0001 |

LVDd (mm) | 51.8±9.2 | 51.1±9.3 | −0.7±5.0 | 0.02 | 53.7±9.6 | 50.2±9.5 | −3.6±6.0 | <0.0001 | 0.008 | 0.16 | <0.0001 |

LVDd >55 mm† | 91/275 (33%) | 83/275 (30%) | −8 (−2.9%) | 0.24 | 152/397 (38%) | 95/397 (24%) | −57 (−14%) | <0.0001 | 0.17 | 0.07 | 0.0004 |

Change in LVDd >0 mm† | n/a | 100/275 (36%) | n/a | n/a | n/a | 105/397 (26%) | n/a | n/a | n/a | 0.006 | n/a |

LVEF (%) | 46.0±15.7 | 49.5±15.8 | 3.5±11.4 | <0.0001 | 44.6±17.3 | 51.1±15.7 | 6.6±13.3 | <0.0001 | 0.18 | 0.11 | 0.004 |

LVEF <40%† | 96/274 (35%) | 76/274 (28%) | −20 (−7.3%) | 0.006 | 173/398 (44%) | 109/398 (27%) | −64 (−16%) | <0.0001 | 0.03 | 0.92 | 0.06 |

Moderate/Severe MR† | 90/270 (33%) | 94/270 (35%) | 3 (1.5%) | 0.58 | 152/395 (38%) | 114/395 (29%) | −38 (−9.6%) | <0.0001 | 0.17 | 0.10 | 0.004 |

Moderate/Severe TR | 73/275 (27%) | 82/275 (30%) | 9 (3.3%) | 0.21 | 119/398 (30%) | 97/398 (24%) | −22 (−5.5%) | 0.020 | 0.34 | 0.12 | 0.02 |

TRPG (mm Hg) | 31.5±12.3 | 30.3±14.0 | 0.37±13.3 | 0.69 | 34.2±13.2 | 27.5±12.2 | −6.0±14.1 | <0.0001 | 0.02 | 0.008 | <0.0001 |

TRPG >31.4 mm Hg† | 77/194 (40%) | 87/194 (45%) | 10 (5.2%) | 0.18 | 157/303 (52%) | 95/303 (31%) | −62 (−20%) | <0.0001 | 0.008 | 0.002 | <0.0001 |

Change in TRPG >0 mm Hg† | n/a | 94/194 (48%) | n/a | n/a | n/a | 98/303 (32%) | n/a | n/a | n/a | 0.0003 | n/a |

Changes in LVDd and TRPG were calculated according to the following equation: (the value at 6-month visit) – (the value at baseline).

*Delta were calculated for continuous variables according to the following equation: (the value at 6-month visit) – (the value at baseline) and for binary variables according to the following equation: (the numbers at 6-month visit) – (the numbers at baseline).

†Risk-adjusting variables selected for the Cox proportional hazards regression model.

LAD, left atrial diameter; LVDd, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; MR, mitral regurgitation; n/a, not available; TR, tricuspid regurgitation; TRPG, tricuspid regurgitant pressure gradient.