Table 2

Changes in echocardiographic parameters from baseline to 6-month visit

No reduction in LAD (n=275)Reduction in LAD (n=398)Between-groups comparison
VariableBaselineFollow-upDelta*P value
(paired)
BaselineFollow-upDelta*P value
(paired)
P value
(baseline)
P value
(follow-up)
P value
(delta)
LAD (mm)43.0±8.946.9±8.84.0±4.1<0.000146.7±8.040.8±8.4−5.8±4.5<0.0001<0.0001<0.0001<0.0001
LAD ≥40 mm†172/275
(63%)
227/275
(83%)
55
(20%)
<0.0001333/398
(84%)
225/398
(57%)
−108
(−27%)
<0.0001<0.0001<0.0001<0.0001
LVDd (mm)51.8±9.251.1±9.3−0.7±5.00.0253.7±9.650.2±9.5−3.6±6.0<0.00010.0080.16<0.0001
LVDd >55 mm†91/275
(33%)
83/275
(30%)
−8
(−2.9%)
0.24152/397
(38%)
95/397
(24%)
−57
(−14%)
<0.00010.170.070.0004
Change in LVDd >0 mm†n/a100/275
(36%)
n/an/an/a105/397
(26%)
n/an/an/a0.006n/a
LVEF (%)46.0±15.749.5±15.83.5±11.4<0.000144.6±17.351.1±15.76.6±13.3<0.00010.180.110.004
LVEF <40%†96/274
(35%)
76/274
(28%)
−20
(−7.3%)
0.006173/398
(44%)
109/398
(27%)
−64
(−16%)
<0.00010.030.920.06
Moderate/Severe MR†90/270
(33%)
94/270
(35%)
3
(1.5%)
0.58152/395
(38%)
114/395
(29%)
−38
(−9.6%)
<0.00010.170.100.004
Moderate/Severe TR73/275
(27%)
82/275
(30%)
9
(3.3%)
0.21119/398
(30%)
97/398
(24%)
−22
(−5.5%)
0.0200.340.120.02
TRPG (mm Hg)31.5±12.330.3±14.00.37±13.30.6934.2±13.227.5±12.2−6.0±14.1<0.00010.020.008<0.0001
TRPG >31.4 mm Hg†77/194
(40%)
87/194
(45%)
10
(5.2%)
0.18157/303
(52%)
95/303
(31%)
−62
(−20%)
<0.00010.0080.002<0.0001
Change in TRPG >0 mm Hg†n/a94/194
(48%)
n/an/an/a98/303
(32%)
n/an/an/a0.0003n/a
  • Changes in LVDd and TRPG were calculated according to the following equation: (the value at 6-month visit) – (the value at baseline).

  • *Delta were calculated for continuous variables according to the following equation: (the value at 6-month visit) – (the value at baseline) and for binary variables according to the following equation: (the numbers at 6-month visit) – (the numbers at baseline).

  • †Risk-adjusting variables selected for the Cox proportional hazards regression model.

  • LAD, left atrial diameter; LVDd, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; MR, mitral regurgitation; n/a, not available; TR, tricuspid regurgitation; TRPG, tricuspid regurgitant pressure gradient.