Baseline characteristics of sepsis patients enrolled in the Sepsis Fast Track programme* (SFT group) or standard of care (non-exposed group)
| Characteristics | SFT group† (n=903) | Non-exposed group‡ (n=2903) |
| Male gender | 526 (58) | 1653 (57) |
| Age (years) (median (IQR)) | 63 (49–74) | 56 (39–70) |
| Age group (years) | ||
| 18–40 | 100 (11) | 647 (22) |
| >40–60 | 277 (31) | 875 (30) |
| >60–70 | 214 (24) | 513 (18) |
| >70 | 312 (35) | 868 (30) |
| Comorbidities | ||
| Hypertension | 239 (26) | 726 (25) |
| Diabetes mellitus | 213 (24) | 594 (20) |
| Chronic kidney disease | 129 (14) | 391 (13) |
| Dyslipidaemia | 66 (7) | 152 (5) |
| Heart disease | 48 (5) | 183 (6) |
| Lung disease | 67 (7) | 239 (8) |
| Liver disease | 33 (4) | 91 (3) |
| Cerebrovascular disease | 29 (3) | 55 (2) |
| Malignancy | 13 (1) | 47 (2) |
| HIV | 6 (1) | 33 (1) |
| Organ dysfunction | ||
| Modified SOFA Score (median (IQR)) | 6 (4–9) | 4 (3–6) |
| Renal dysfunction§ | 706 (78) | 1846 (64) |
| Cardiovascular dysfunction§ | 811 (90) | 1532 (53) |
| Coagulation dysfunction§ | 419 (46) | 1562 (54) |
| Liver dysfunction§ | 311 (34) | 822 (28) |
| Respiratory dysfunction§ | 337 (37) | 853 (29) |
| Central nervous system dysfunction§ | 166 (18) | 530 (18) |
| Transferred from other hospitals | 874 (97) | 2372 (84) |
| Duration of symptoms (median (IQR)) | 2 (1–3) | 3 (1–5) |
| ≤2 days | 505 (56) | 1191 (41) |
| 3–7 days | 362 (40) | 1488 (51) |
| >7 days | 36 (4) | 224 (8) |
| Presenting clinical syndromes¶ | ||
| Septic shock | 687 (76) | 733 (25) |
| Acute febrile illness | 206 (23) | 940 (32) |
| Lower respiratory infection | 223 (25) | 890 (31) |
| Sepsis | 225 (25) | 273 (9) |
| Others | 13 (1) | 456 (16) |
| Diarrheal illness | 150 (17) | 264 (9) |
| Direct admission to the ICU | 170 (19) | 128 (4) |
| Admission to the ICU within 24 hours of admission | 270 (29) | 370 (13) |
| Blood culture positive for pathogenic organisms | 175 (19) | 347 (12) |
| Year | ||
| 2013 | N/A | 1047 (26) |
| 2014 | N/A | 1156 (29) |
| 2015 | 369 (39) | 956 (24) |
| 2016 | 556 (59) | 869 (21) |
| 2017 | 14 (1) | 22 (1) |
Values are number (%) unless stated otherwise.
*SFT programme was implemented at the study hospital in January 2015.
†Nine hundred and three patients of the Ubon-sepsis cohort were enrolled in SFT programme after the implementation of the SFT programme (figure 1).
‡Included 1636 and 1267 patients in the Ubon-sepsis cohort before and after the implementation of the SFT programme, respectively.
§Organ dysfunction defined as modified SOFA Score was ≥1 for each organ system.16
¶Patients may have more than one presenting clinical syndrome.
ICU, intensive care unit; SOFA, Sequential Organ Failure Assessment.