Table 2

Effect of proton pump inhibitor (PPI) use on the risk of acute kidney injury (AKI)

Exposure of PPIsCases (%), n=317Controls (%), n=3150OR (95% CI)*OR (95% CI), adjusted†
Current use148 (46.7)655 (20.8)4.09 (3.09 to 5.44)2.79 (2.06 to 3.79)
Recent use23 (7.3)416 (13.2)1.26 (0.72 to 2.13)1.02 (0.57 to 1.76)
Past use146 (46.1)2079 (66.0)ReferenceReference
  • Current use, the drug use within 30 days before the index date; recent use, the drug use within 90 days, but not within 30 days, before the index date; past use, the drug use after the cohort entry, but not within 90 days before the index date.

  • *ORs of AKI for current/recent PPI users compared with past users were estimated using a conditional logistic regression model.

  • †Adjusted ORs were estimated by entering the potential confounders into the model.