Table 4

Description of the adverse effects reported by the included studies (n=5)

Author/yearIntervention group
(number of AE)
Description of the effects
(number of AE)
Comparator group
(number of AE)
Description of the effects
(number of AE)
Dantas et al27Midazolam
15 mg (54)
Drowsiness (33), muscular relaxation (11), dizziness (7), gastrointestinal problems (1), amnesia (1), insomnia (1)Passiflora incarnate L. (32)Drowsiness (20), muscular relaxation (8), dizziness (2), allergy (1), epistaxis (1)
Manani et al21Diazepam
15 mg (36)
Drowsiness (10), vertigo (3), cognitive impairment (6)Trazodone 50 mg (28)Drowsiness (10), vertigo (5), blurred vision (2), cognitive impairment (11)
Trazodone 25 mg (18)Drowsiness (15), vertigo (9), blurred vision (6), cognitive impairment (6)
Placebo (18)Drowsiness (12), vertigo (1), blurred vision (2), cognitive impairment (3)
Pinheiro et al30Valeriana officinalis (16)Drowsiness (9), muscular relaxation (7)Placebo (11)Drowsiness (7), muscular relaxation (4)
Rodrigo, Cheung22Midazolam
15 mg (46)
Drowsiness (17), dizziness (8), memory loss (3), excitability(5), depression (5), nausea (5), vomiting (2), headache (3)Placebo (29)Drowsiness (9), dizziness (4), memory loss and excitability (1), depression (1), blurred vision (1), insomnia (5), hallucinations (1), nausea (4), vomiting (1), headache (2)
Studer et al29Midazolam 7.5 mg (6)Dizziness (3); nausea, headache and fatigue (1); cognitive deficit (2)Clonidine 0.15 mg (6)Nausea (2), drowsiness (3), fainting (1)
  • AE, adverse effects.