Table 1

Characteristics of the studies included (n=10 studies)

VariablesStudies (n)Population (n)
Study population10327
Women (n=282)8164 (58.2%)
Benzodiazepines
 Alprazolam (0.25, 0.5 and 0.75 mg)136
 Diazepam (5, 10 and 15 mg)349
 Midazolam (7.5 and 15 mg)497
 Lorazepam (1 mg)110
Herbal medicines
Erythrina mulungu 500 mg130
Passiflora incarnata L. 260 mg140
Valeriana officinalis 100 mg110
Clinical condition
 Dental extraction6180
 Dental implants245
 Other dental surgery2102
Country
 Brazil5135
 USA148
 Italy182
 Switzerland112
 China130
 India120
Year of publication
 1979–19882112
 1989–1998148
 1999–200800
 2009–20177167
Funded by industry
 Yes130
 Not specified4157
 Not funded5140