Table 6

Summary of recommendations for approaches to diagnosis of neonatal hyperbilirubinemia

NICEMaHTASQCGISNAAPTPANPAINSSAPSSNCPSChPS
Clinical assessment
Visual assessment (do not rely on it alone)++NA++NANA++NANA
Measurement of bilirubin
TCB++++++++++++
TSB++++++++++++
B/ANANA+NANANANANANA+
IcterometerNANANANANANANANANA+
Test for prolonged jaundice
Blood group compatibility++++++NA++++NA
DAT++++++NA++++NA
G6PD++++++NA++NA+NA
Conjugated component of bilirubin+NA+NA++NA++++NA
Complete blood count++++++NANANANA+NA
Septic workup (if suspected)+++NA++NANA+NA+NA
Thyroid functionsNANA+NA++NA++NANANA
Urinalysis, urine cultureNANA+NA++NA++NANANA
Reticulocyte countNA++NA++NANANANANANA
  • AAP, American Academy of Pediatrics Subcommittee on Hyperbilirubinemia (America); ChPS, Chinese Pediatric Society, Chinese Medical Association (China); CPS, Canadian Pediatric Society, Fetus and Newborn Committee (Canada); DAT, direct antiglobulin test; G6PD, Glucose-6-phosphate dehydrogenase; INS, Israel Neonatal Society (Israel); ISN, Italian Society of Neonatology (Italy); MaHTAS, Malaysia Health Technology Assessment Section (Malaysia); NA, not available; NICE, National Institute for Health and Care Excellence (the UK); NPA, Norwegian Pediatric Association (Norway); QCG, Queensland Clinical Guidelines (Australia); SAP, Spanish Association of Pediatrics (Spain); SSN, Swiss Society of Neonatology (Swiss); TCB, transcutaneous bilirubinometer; TPA, Turkish Paediatric Association (Turkey).