Clinical and laboratory data to explore mechanisms of RV dysfunction
| Mechanistic category | Clinical and laboratory data |
| ARDS | Requirement for prone ventilation |
| Murray lung injury score and components | |
| Requirement for paralysis | |
| Compliance | |
| Arterial blood gas analysis | |
| Referral for extracorporeal membrane oxygenation (ECMO) | |
| Disordered coagulation | D-dimer |
| Systemic anticoagulation (prophylactic/therapeutic) | |
| Confirmed or suspected pulmonary thromboembolism | |
| Prothrombin time (PT)/activated partial thromboplastin time (aPTT) | |
| Platelet count | |
| Myocardial injury | LV function (from TTE) |
| ScvO2 | |
| Natriuretic peptides (BNP or NT-proBNP) | |
| Troponin | |
| Acute coronary syndrome treatment | |
| ECG changes | |
| Inotropic/vasopressor support | |
| History/treatment of arrhythmia | |
| Ventilation | Fraction of inspired oxygen (FiO2) |
| Ventilatory mode | |
| Positive end-expiratory pressure | |
| Peak airway pressure | |
| Driving pressure | |
| Respiratory rate |
Clinical and laboratory data to explore mechanisms of RV dysfunction in each mechanistic category: ARDS, disordered coagulation, myocardial injury and ventilation.
ARDS, acute respiratory distress syndrome; BNP, brain natriuretic peptide; LV, left ventricle; NT-proBNP, N-terminal pro b-type natriuretic peptide; RV, right ventricle; TTE, transthoracic echocardiogram.