Without propensity-score matched (n=1522) | With propensity-score matched (n=284) | |||||
Patients without PAD (n=1451) | Patients with PAD (n=71) | P value | Patients without PAD (n=213) | Patients with PAD (n=71) | P value | |
Female (%) | 33.10 | 16.90 | 0.007 | 15.00 | 16.90 | 0.850 |
Age (years) [mean (SD)] | 67.40 (13.10) | 69.90 (12.10) | 0.106 | 69.10 (12.20) | 69.90 (12.10) | 0.607 |
History | ||||||
Diabetes (%) | 50.20 | 67.60 | 0.006 | 67.10 | 67.60 | 1.000 |
CAD (%) | 15.90 | 36.60 | <0.001 | 40.40 | 36.60 | 0.674 |
PCI (%) | 9.60 | 21.10 | 0.003 | 26.80 | 21.10 | 0.431 |
CABG (%) | 3.80 | 14.10 | <0.001 | 9.90 | 14.10 | 0.442 |
Aortic dissection (%) | 5.00 | 15.50 | <0.001 | 7.00 | 15.50 | 0.057 |
Admission of HF (%) | 19.40 | 42.30 | <0.001 | 29.10 | 42.30 | 0.057 |
Stroke (%) | 9.10 | 7.00 | 0.704 | 14.10 | 7.00 | 0.175 |
Cause of CKD | 0.294 | 0.091 | ||||
Diabetes (%) | 42.50 | 59.20 | 58.70 | 59.20 | ||
Nephrosclerosis (%) | 25.30 | 25.40 | 25.40 | 25.40 | ||
CGN (%) | 15.60 | 4.20 | 8.50 | 4.20 | ||
Others, unknown (%) | 4.30 | 4.20 | 2.30 | 4.20 | ||
Vital data | ||||||
Pre-dialysis SBP (mmHg) [mean (SD)] | 151.10 (25.90) | 151.70 (29.50) | 0.843 | 151.80 (28.30) | 151.70 (29.50) | 0.977 |
Cardiac ultrasonography | ||||||
EF (%) (mean (SD)) | 60.90 (12.20) | 55.80 (13.70) | 0.001 | 59.80 (13.80) | 55.80 (13.70) | 0.049 |
Chest X-ray | ||||||
CTR (%) (mean (SD)) | 55.20 (7.20) | 55.20 (7.10) | 0.973 | 55.30 (6.80) | 55.20 (7.10) | 0.885 |
Administration | ||||||
ARB or ACEI (%) | 60.60 | 56.30 | 0.554 | 59.20 | 56.30 | 0.781 |
BB (%) | 34.00 | 47.90 | 0.024 | 49.30 | 47.90 | 0.945 |
Statin (%) | 39.40 | 53.50 | 0.024 | 58.70 | 53.50 | 0.533 |
VDRA (%) | 26.90 | 29.60 | 0.726 | 27.20 | 29.60 | 0.819 |
Antiplatelets (%) | 28.90 | 56.30 | <0.001 | 58.20 | 56.30 | 0.890 |
ESA (%) | 85.80 | 87.30 | 0.861 | 89.70 | 87.30 | 0.742 |
Laboratory data | ||||||
WBC (×109/L) (mean (SD)) | 6.73 (3.13) | 7.21 (3.58) | 0.214 | 6.70 (2.72) | 7.21 (3.58) | 0.217 |
Hb (g/L) (mean (SD)) | 93.70 (15.50) | 94.00 (14.50) | 0.887 | 96.20 (14.30) | 94.00 (14.50) | 0.275 |
Plt (×109/L) (mean (SD)) | 182.40 (76.20) | 181.70 (81.90) | 0.943 | 179.00 (73.90) | 181.70 (81.90) | 0.796 |
Alb (g/dL) (mean (SD)) | 3.21 (0.59) | 3.02 (0.62) | 0.010 | 3.20 (0.60) | 3.02 (0.62) | 0.032 |
BUN (mg/dL) (mean (SD)) | 92.02 (30.69) | 86.68 (24.84) | 0.149 | 87.14 (27.58) | 86.68 (24.84) | 0.901 |
Cr (mg/dL) (mean (SD)) | 9.03 (3.24) | 7.74 (2.22) | 0.001 | 8.47 (2.82) | 7.74 (2.22) | 0.049 |
eGFR (mL/min/1.73 m2) (mean (SD)) | 5.40 (2.23) | 6.34 (1.83) | 0.001 | 6.05 (2.47) | 6.34 (1.83) | 0.368 |
Na (mEq/L) (mean (SD)) | 137.88 (4.41) | 137.93 (3.91) | 0.933 | 138.36 (4.56) | 137.93 (3.91) | 0.475 |
K (mEq/L) (mean (SD)) | 4.56 (0.84) | 4.43 (0.81) | 0.194 | 4.51 (0.83) | 4.43 (0.81) | 0.492 |
Adjusted Ca (mg/dL) (mean (SD)) | 8.59 (1.06) | 9.06 (0.93) | <0.001 | 8.71 (0.96) | 9.06 (0.93) | 0.007 |
P (mg/dL) (mean (SD)) | 6.40 (1.89) | 5.76 (1.56) | 0.005 | 5.96 (1.63) | 5.76 (1.56) | 0.372 |
Mg (mg/dL) (mean (SD)) | 2.15 (0.49) | 2.17 (0.44) | 0.826 | 2.22 (0.46) | 2.17 (0.44) | 0.497 |
UA (mg/dL) (mean (SD)) | 8.80 (2.44) | 8.64 (2.27) | 0.582 | 8.75 (2.49) | 8.64 (2.27) | 0.731 |
LDL C (mg/dL) (mean (SD)) | 89.97 (34.25) | 87.08 (37.14) | 0.525 | 87.07 (32.01) | 87.08 (37.14) | 0.999 |
CRP (mg/dL) (mean (SD)) | 1.82 (4.14) | 2.39 (4.68) | 0.271 | 1.61 (3.30) | 2.39 (4.68) | 0.137 |
β2MG (ng/dL) (mean (SD)) | 19.32 (5.78) | 17.33 (5.05) | 0.027 | 17.95 (5.04) | 17.33 (5.05) | 0.497 |
TSAT (%) (mean (SD)) | 27.16 (16.60) | 25.44 (17.95) | 0.438 | 25.41 (14.74) | 25.44 (17.95) | 0.992 |
Ferritin (ng/dL) (mean (SD)) | 222.28 (1009.80) | 226.65 (395.74) | 0.972 | 171.44 (208.99) | 226.65 (395.74) | 0.153 |
Outcome | ||||||
Infection-related death (%) | 3.40 | 8.50 | 0.062 | 3.80 | 8.50 | 0.206 |
CVD-related death (%) | 6.60 | 11.60 | 0.167 | 8.20 | 11.60 | 0.537 |
All-cause death (%) | 17.00 | 33.80 | 0.001 | 21.60 | 33.80 | 0.056 |
ACEI, ACE inhibitor; Adjusted Ca, adjusted calcium; Alb, albumin; ARB, angiotensin receptor blocker; BB, beta blocker; BUN, blood urea nitrogen; Ca, calcium; CABG, coronary artery bypass grafting; CAD, coronary artery disease; CGN, chronic glomerulonephritis; CKD, chronic kidney disease; Cr, creatinine; CRP, C reactive protein; CTR, cardiothoracic ratio; CVD, cardiovascular disease; EF, ejection fraction; eGFR, estimated glomerular filtration rate; ESA, erythropoietin stimulating agent; hb, haemoglobin; HF, heart failure; K, potassium; LDL-C, low-density lipoprotein cholesterol; β2MG, beta-2 microglobulin; Mg, magnesium; Na, sodium; P, phosphate; PAD, peripheral arterial disease; PCI, percutaneous coronary intervention; Plt, platelet; SBP, systolic blood pressure; TSAT, transferrin saturation; UA, uric acid; VDRA, vitamin D receptor agonist; WBC, white blood cells.