Table 2

Overview of the key features of a simulation study (first column) with the NHANES example described in the section "An example of a statistical simulation" (second column)

Key features of simulation studiesNHANES example
AimsTo quantify the impact of measurement error.
Data generating mechanismTake real data, add normally distributed random error to the exposure of interest (HbA1c) and/or the confounder (BMI).
Method of analysisMultivariable linear regression, first on data with no measurement error, then on data with measurement error added.
Performance measureBias in regression coefficient for exposure of interest (HbA1c).
Number of repetitions1000
  • This table is inspired by the ‘ADEMP’ system (aims, data generating mechanisms, estimands, methods and performance measures) introduced previously in statistical literature.3

  • BMI, body mass index; HbA1c, glycated haemoglobin; NHANES, National Health and Nutrition Examination Survey.