Problem | Possible strategies | Reference |
High prevalence of vancomycin-resistant enterococci or vancomycin usage | Vancomycin reduction guideline to cut down the overuse | Chiu et al.31 . |
High prevalence of multidrug-resistant Gram-negative bacterial infections | Suppression of excess usage of third-generation cephalosporins. | Calil et al.32 |
High broad-spectrum antibiotic usage | Reduce use of broad-spectrum perioperative antibiotic prophylaxis for clean surgical procedures; avoid prolonged duration of postoperative prophylaxis days of therapy of perioperative prophylaxis >48 hours; avoid prolonged duration of culture-negative sepsis | Cantey et al.4 |