Table 3

Relationship between long-term conditions and major adverse cardiovascular events in participants with and without self-reported rheumatoid arthritis (RA) using age-adjusted multivariate Cox’s proportional hazards regression analysis

Risk of MACE
Comorbidity status (reference: no RA and no other long-term conditions)Adjusted for sex and Townsend score HR (95% CI)Adjusted for sex, Townsend score, alcohol status and smoking status HR (95% CI)Adjusted for sex, Townsend score, alcohol status, smoking status, BMI and physical activity HR (95% CI)Adjusted for sex, Townsend score, alcohol status, smoking status, BMI, physical activity and rheumatoid factor status HR (95% CI)Number of MACE (%)
No other long-term conditionsRA1.79 (1.33 to 2.39)1.69 (1.26 to 2.27)1.64 (1.21 to 2.20)1.63 (1.21 to 2.21)46 (3.4%)
1 other long-term conditionNo RA1.30 (1.24 to 1.36)1.28 (1.22 to 1.34)1.26 (1.20 to 1.3201.24 (1.19 to 1.31)4512 (2.8%)
RA2.08 (1.66 to 2.61)1.91 (1.52 to 2.41)1.87 (1.48 to 2.35)1.68 (1.31 to 2.15)78 (4.6%)
2–3 other long-term conditionsNo RA1.86 (1.78 to 1.94)1.78 (1.70 to 1.86)1.67 (1.60 to 1.75)1.66 (1.59 to 1.74)6208 (4.6%)
RA2.72 (2.28 to 3.24)2.49 (2.09 to 2.98)2.19 (1.82 to 2.64)2.09 (1.73 to 2.54)131 (6.7%)
≥4 other long-term conditionsNo RA3.04 (2.87 to 3.22)2.76 (2.60 to 2.93)2.40 (2.26 to 2.56)2.37 (2.23 to 2.53)1980 (8.2%)
RA4.79 (3.79 to 6.04)4.07 (3.21 to 5.16)3.52 (2.73 to 4.52)3.39 (2.61 to 4.40)73 (11.7%)
  • Unless otherwise shown, Cox’s proportional hazards p<0.01.

  • BMI, body mass index; MACE, major adverse cardiovascular events.