Table 2

Number of registered clinical studies worldwide and those sponsored by China, annually and cumulatively to December 2018

YearAnnual registrations sponsored by ChinaGlobal annual registrationsCumulative registrations sponsored by ChinaGlobal cumulative registrations
ChiCTRClinicalTrials.govOther registriesTotalChiCTRClinicalTrials.govOther registriesTotal
Pre-20093063485070491 3843063485070491 384
20093043032262924 843610651721333116 227
20104043523078626 886101410031022119143 113
201165550446120528 234166915071483324171 347
2012103569330175832 148270422001785082203 495
2013107895544207733 550378231552227159237 045
20141548111822268837 898533042732449847274 943
20151742145635323341 2157072572927913 080316 158
20162489206344459647 4129561779232317 676363 570
20173835233153621953 06113 39610 12337623 895416 631
20186087250570866261 63019 48312 62844632 557478 261
TotalRegistrations by China 2009–2018478 261Proportion of registrations by China100%
19 17712 28039631 85360%39%1%478 261
  • Data note: In the 20 405 ChiCTR-retrieved registration entries on ICTRP up to 2018, 372 redundant entries and 413 missing entries were found when compared with the retrieval results on the ChiCTR website. The redundant entries were deleted, and the missing entries were supplemented by individual records from the ChiCTR website. Furthermore, there were 29 registration entries with the wrong registration year in 1990 and one registered study with the wrong registration date beyond the actual date. The registration year was determined according to ‘Study Execute Time’, ‘Date of Last Refreshed on’ and ‘Registration Status’. The static copy of the AACT database for ClinicalTrials.gov was downloaded, and the registration date was based on the data field of the ‘study first posted date’. After removing 811 trials with a study title of ‘trials of device that is not approved or cleared by the US FDA’, 292 582 studies registered on ClinicalTrials.gov up to 2018 were included. Duplicate registration entries were only excluded for registrations primarily sponsored by China.

  • ChiCTR, Chinese Clinical Trial Registry; ISRCTN, International standard randomised controlled trial number.