First author, year of publication | Country | Participants | Kind of participants | Years | Yielding /person-years | Outcome | SMR | CI |
Irvine,22 1993 | England/Wales | 6209 | Male pilots (all heart disease) | 1950–1992 | 143 506 | ↓ CD | 0.39 | 0.33 to 46.2 |
Male pilots (IHD) | 0.39 | 0.32 to 45.9 | ||||||
1153 | Male flight engineers (all CD) | 29 094 | ↓ CD | 0.41 | 0.28 to 56.8 | |||
Male flight engineers (IHD) | 0.40 | 0.27 to 0.57 | ||||||
Band,16 1996 | Canada | 2740 | Male pilots (circulatory system) | 1950–1992 | 62 449 | ↓ CD | 0.6 | 0.49 to 0.72 |
Male pilots (IHD) | ↓ CD | 0.57 | 0.45 to 0.71 | |||||
Male pilots (AMI) | ↓ CD | 0.61 | 0.45 to 0.80 | |||||
Male pilots (cerebrovascular disease) | ↓ CD | 0.55 | 0.27 to 0.99 | |||||
Male pilots (aortic aneurysm) | ↓ CD | 0.95 | 0.26 to 2.45 | |||||
Ballard,15 2002 | Italy | 3022 | Male cockpit crew members (CD) | 1965–1996 | 54 072 | ↓ CD | 0.76 | 0.57 to 0.99 |
Male cockpit crew members (AMI) | ↓ CD | 0.91 | 0.62 to 1.29 | |||||
Male cockpit crew members (CVD) | ↓ CD | 0.28 | 0.11 to 0.57 | |||||
3418 | Male cabin attendants (CD) | 49 391 | ↓ CD | 0.64 | 0.36 to 1.05 | |||
Male cabin attendants (AMI) | ↓ CD | 0.54 | 0.22 to 1.11 | |||||
Male cabin attendants (CVD) | ↓ CD | 0.61 | 0.17 to 1.55 | |||||
6440 | Female cabin attendants (CD) | 53 305 | ↑ CD | 1.28* | 0.16 to 4.63 | |||
Female cabin attendants (CVD) | ↓ CD | 0.81 | 0.10 to 2.94 | |||||
Zeeb,18 2002 | German | 6061 | Male cockpit crew (all cardiovascular) | 1960–1997 | 105 037 | ↓ CD | 0.46 | 0.34 to 0.62 |
Male cockpit crew (hypertension) | ↓ CD | 0.24 | 0.01 to 1.39 | |||||
Male cockpit crew (AMI) | ↓ CD | 0.43 | 0.28 to 0.65 | |||||
Male cockpit crew (other IHD) | ↓ CD | 0.65 | 0.36 to 1.10 | |||||
Male cockpit crew (other CD) | ↓ CD | 0.41 | 0.22 to 0.72 | |||||
Blettner,23 2002 | German | 16 014 | Female cabin attendants (CVD) | 1960–1997 | 188 218 | ↓ CD | 0.5 | 0.10 to 1.60 |
Female cabin attendants (all CD) | ↓ CD | 0.23 | 0.04 to 0.74 | |||||
Female cabin attendants (other IHD) | ↓ CD | 0.75 | 0.02 to 4.62 | |||||
Female cabin attendants (Hp) | ↑ CD | 1.17* | 0.03 to 7.15 | |||||
Female cabin attendants (other CD) | ↓ CD | 0.16 | 0.00 to 0.98 | |||||
4537 | Male cabin attendants (CVD) | 606 650 | ↓ CD | 0.26 | 0.01 to 1.56 | |||
Male cabin attendants (all CD) | ↓ CD | 0.41 | 0.18 to 0.86 | |||||
Male cabin attendants (other IHD) | ↓ CD | 0.67 | 0.08 to 2.63 | |||||
Male cabin attendants (Hp) | ↓ CD | 0.18 | 0.02 to 0.71 | |||||
Male cabin attendants (other IHD) | ↓ CD | 0.75 | 0.23 to 1.89 | |||||
Qiang,30 2003 | USA | 3263 | Male commuter/air taxi pilots | 1987–1997 | 35 427 | ↓ CD | 0.18 | 0.15 to 0.22 |
Zeeb,19 2003 | German | 6061 | Male cockpit crew <30 years (all CV) | 1960–1997 | 105 000 | ↓ CD | 0.2 | 0.1 to 0.5 |
Male cockpit crew <30 years (AMI) | ↓ CD | 0.2 | 0.1 to 0.5 | |||||
Male cockpit crew <30 years (other IHD) | ↓ CD | 0.3 | 0.0 to 1.3 | |||||
Male cockpit crew <30 years (other CD) | ↓ CD | 0.32 | 0.1 to 0.9 | |||||
Male cockpit crew >30 years (all CV) | ↓ CD | 0.6 | 0.4 to 0.8 | |||||
Male cockpit crew >30 years (AMI) | ↓ CD | 0.6 | 0.4 to 0.9 | |||||
Male cockpit crew >30 years (other IHD) | ↓ CD | 0.75 | 0.4 to 1.3 | |||||
Male cockpit crew >30 years (other CD) | ↓ CD | 0.46 | 0.2 to 0.9 | |||||
Male cockpit crew <55 years (all CV) | ↓ CD | 0.4 | 0.2 to 0.6 | |||||
Male cockpit crew <55 years (AMI) | ↓ CD | 0.3 | 0.1 to 0.7 | |||||
Male cockpit crew <55 years (other IHD) | ↓ CD | 0.6 | 0.1 to 1.8 | |||||
Male cockpit crew <55 years (other CD) | ↓ CD | 0.4 | 0.1 to 0.9 | |||||
Male cockpit crew >55 years (all CV) | ↓ CD | 0.5 | 0.4 to 0.7 | |||||
Male cockpit crew >55 years (AMI) | ↓ CD | 0.5 | 0.3 to 0.8 | |||||
Male cockpit crew >55 years (other IHD) | ↓ CD | 0.7 | 0.3 to 1.2 | |||||
Male cockpit crew >55 years (other CD) | ↓ CD | 0.5 | 0.2 to 0.9 | |||||
Paridou,29 2003 | Greece | 843 | Male cockpit crew | 1960–1997 | 17 587 | ↓ CD | 0.2 | 0.0 to 0.9 |
Blettner,24 2003 | Denmark, Finland, Germany, Great Britain, Greece, Iceland, Italy, Norway and Sweden | 27 797 | Male cockpit crew (CVD) | 1921–1997 | 547 564 | ↓ CD | 0.51 | 0.41 to 0.62 |
Male cockpit crew (all CV) | ↓ CD | 0.51 | 0.46 to 0.56 | |||||
Male cockpit crew (AMI) | ↓ CD | 0.50 | 0.44 to 0.57 | |||||
Zeeb,20 2003 | Denmark, Finland, Germany, Greece, Iceland, Italy, Norway and Sweden | 33 063 | Female cabin crew (All CD) | 1960–1997 | 485 831 | ↓ CD | 0.51 | 0.27 to 0.91 |
Female cabin crew (CVD) | ↓ CD | 0.27 | 0.14 to 0.49 | |||||
11 079 | Male cabin crew (all CD) | 170 634 | ↓ CD | 0.61 | 0.33 to 1.12 | |||
Male cabin crew (CVD) | ↓ CD | 0.62 | 0.48 to 0.83 | |||||
Linnersjö,26 2011 | Sweden | 1478 | MCP (30–39 years) | 1957–1994 | 33 127 | … | … | … |
MCP (40–49 years) | ↓ CD | 0.26 | 0.03 to 0.96 | |||||
MCP (50–59 years) | ↓ CD | 0.48 | 0.22 to 0.91 | |||||
MCP (60–69 years) | ↓ CD | 0.44 | 0.23 to 0.76 | |||||
MCP (70–79 years) | ↓ CD | 0.45 | 0.23 to 0.81 | |||||
MCP (≥80 years) | ↑ CD | 1.4* | 0.45 to 3.27 | |||||
2166 | Male military pilots (30–39 years) | 52 141 | ↑ CD | 1.08 | 0.13 to 3.90 | |||
Male military pilots (40–49 years) | ↓ CD | 0.33 | 0.09 to 0.85 | |||||
Male military pilots (50–59 years) | ↓ CD | 0.41 | 0.23 to 0.67 | |||||
Male military pilots (60–69 years) | ↓ CD | 0.58 | 0.40 to 0.76 | |||||
Male military pilots (70–79 years) | ↓ CD | 0.5 | 0.35 to 0.65 | |||||
Male military pilots (≥80 years) | ↓ CD | 0.75 | 0.47 to 1.03 | |||||
991 | MMN and mechanics (30–39 years) | 24 252 | ↑ CD | 1.27* | 0.03 to 7.08 | |||
MMN and mechanics (40–49 years) | =CD | 1.05 | 0.38 to 2.28 | |||||
MMN and mechanics (50–59 years) | ↓ CD | 0.76 | 0.42 to 1.28 | |||||
MMN and mechanics (60–69 years) | ↓ CD | 0.65 | 0.39 to 0.92 | |||||
MMN and mechanics (70–79 years) | ↓ CD | 0.99 | 0.66 to 1.32 | |||||
MMN and mechanics (≥80 years) | ↓ CD | 0.52 | 0.19 to 1.13 | |||||
632 | Male cabin crew | 14 658 | ↓ CD | 0.50 | 0.28 to 0.73 | |||
2324 | Female cabin crew | 48 001 | ↓ CD | 0.31 | 0.09 to 0.80 | |||
Houston,21 2011 | UK | 14 379 | Male commercial pilots | 2008 | … | ↓ CD | … | … |
Female commercial pilots | … | ↓ CD | … | … | ||||
De Stavola,31 2012 | UK | 15 881 | Male flight crew | 1989–1999 | 258 650 | ↓ CD | 0.19 | 0.16 to 0.23 |
446 | Female flight crew | ↓ CD | ||||||
Yong,17 2014 | USA | 5964 | CCC (cerebrovascular) | 1960–2008 | 202 316 | ↓ CD | 0.61 | 0.50 to 0.74 |
CCC (rheumatic heart) | ↓ CD | 0.3 | 0.06 to 0.88 | |||||
CCC (all ischaemic heart) | ↓ CD | 0.49 | 0.43 to 0.55 | |||||
CCC (AMI) | ↓ CD | 0.37 | 0.31 to 0.43 | |||||
CCC (all other CD) | ↓ CD | 0.47 | 0.39 to 0.56 | |||||
Hammer,25 2014 | Denmark, Finland, Germany, Greece, Iceland, Italy, Norway, Sweden, UK and USA | 36–816 | Male cockpit crew (all CD) | 21.7 | 2 032 279 | ↓ CD | 0.42 | 0.37 to 0.46 |
Male cockpit crew (RHD) | ↓ CD | 0.11 | 0.02 to 0.35 | |||||
Male cockpit crew (IHD) | ↓ CD | 0.36 | 0.29 to 0.44 | |||||
Male cockpit crew (AMI) | ↓ CD | 0.45 | 0.38 to 0.52 | |||||
Male cockpit crew (Hp) | ↓ CD | 0.42 | 0.21 to 0.74 | |||||
Male cockpit crew (other CD) | ↓ CD | 0.47 | 0.37 to 0.59 | |||||
12 288 | Male cabin crew (all CD) | ↓ CD | 0.72 | 0.60 to 0.85 | ||||
Male cabin crew (RHD) | … | … | … | |||||
Male cabin crew (IHD) | ↓ CD | 0.86 | 0.64 to 1.13 | |||||
Male cabin crew (AMI) | ↓ CD | 0.58 | 0.44 to 0.76 | |||||
Male cabin crew (Hp) | =CD | 1.03 | 0.45 to 2.00 | |||||
Male cabin crew (other CD) | ↓ CD | 0.76 | 0.53 to 1.06 | |||||
44 667 | Female cabin crew (RHD) | … | … | … | ||||
Female cabin crew (IHD) | ↓ CD | 0.3 | 0.16 to 0.50 | |||||
Female cabin crew (AMI) | ↓ CD | 0.27 | 0.16 to 0.43 | |||||
Female cabin crew (Hp) | ↓ CD | 0.38 | 0.12 to 0.91 | |||||
Female cabin crew (other CD) | ↓ CD | 0.54 | 0.37 to 0.77 | |||||
McNeely,27 2014 | USA | 3208 | Female flight attendants (CD) | 2005–2006 2007–2008 | … | ↑ CD | (SPR) 3.51 | 2.72 to 4.30 |
Female flight attendants (Hp) | … | ↓ CD | (SPR) 0.54 | 0.49 to 0.58 | ||||
802 | Male flight attendants (CD) | … | ↑ CD | (SPR) 1.39 | 0.79 to 1.98 | |||
Male flight attendants (Hp) | … | =CD | (SPR) 1.00 | 0.86 to 1.19 | ||||
McNeely,28 2018 | USA | 998 | Male flight attendants (CD) | 2014–2015 | … | ↓ CD | (SPR) 0.73 | 0.47 to 1.15 |
Male flight attendants (Hp) | … | ↓ CD | (SPR) 0.63 | 0.56 to 0.70 | ||||
4368 | Female flight attendants (CD) | … | ↓ CD | (SPR) 0.53 | 0.29 to 0.96 | |||
Female flight attendants (Hp) | … | ↓ CD | (SPR) 0.44 | 0.30 to 0.50 |
↑, increase; ↓, decrease; =, no change.
*Standardised mortality ratio (SMR) higher than 1.
AMI, acute myocardial infarction; CCC, commercial cockpit crew; CD, cardiovascular disease; CVD, cerebral vascular disease; Hp, hypertension; IHD, ischaemic heart disease; MCP, male commercial pilots; MMN, male military navigators; RHD, rheumatic heart disease; SPR, standardised prevalence ratio.