Table 4

Risk of all cause death in 2016–2017 among patients coprescribed BZDs and opioids stratified by OME (n=31 998)

CategoryOME
<50 (reference group)50–90>90
OR (P value) 95% CIOR (P value) 95% CIOR (P value) 95% CI
Overall population11.72 (<0.001) 1.35 to 2.193.13 (<0.001) 2.50 to 3.92
 Female11.76 (<0.001) 1.25 to 2.483.22 (<0.001) 2.35 to 4.40
 Male11.68 (0.003) 1.19 to 2.373.04 (<0.001) 2.20 to 4.19
Age at death
 18–4510.90 (0.83) 0.35 to 2.312.31 (0.08) 0.92 to 5.85
 46–6512.19 (<0.001) 1.41 to 3.392.78 (<0.001) 1.84 to 4.18
 >6511.60 (0.003) 1.18 to 2.183.41 (<0.001) 2.57 to 4.52
  • Buprenorphine and methadone were excluded.

  • BZD, benzodiazepines/Z-drugs; OME, oral morphine equivalent.