Base case clinical outcomes for model comparing universal repeat screening of syphilis in late pregnancy with single screening
| Screening strategy | Syphilis antenatal screens | Women treated for syphilis | False positive maternal syphilis | Intrauterine fetal demise (all causes)* | Preterm deliveries (all causes)* | Neonatal deaths (all causes)* | Congenital syphilis cases |
| Existing: single screen | |||||||
| Estimate | 725 891 | 1705 | 1451 | 2904.4 | 54 228 | 1446.5 | 8.8 |
| 95% CI† | 725 891 to 725 891 | 1698 to 1737 | 1443 to 1482 | 2890 to 2916 | 53 905 to 54 282 | 1441 to 1457 | 8.7 to 8.9 |
| Alternative: repeat screen | |||||||
| Estimate | 1 411 696 | 3089 | 2823 | 2904.1 | 54 226 | 1446.4 | 3.3 |
| 95% CI† | 1 411 456 to 1 411 503 | 3074 to 3150 | 2806 to 2883 | 2889 to 2915 | 53 903 to 54 280 | 1441 to 1457 | 3.3 to 3.3 |
| Difference | 685 805 | 1384 | 1372 | −0.3 | −2 | −0.1 | −5.5 |
*These adverse pregnancy outcomes are all-cause outcomes for all 725 891 women screened, including the small number with syphilis infection.
†95% confidence interval, calculated using probabilistic sensitivity analysis.