Table 3

Base case short-term annual healthcare costs from model comparing universal repeat screening of syphilis in late pregnancy with single screening

Screening strategyTotal healthcare costsCost breakdown*
Antenatal syphilis screeningSyphilis treatment (in pregnant women found positive)Perinatal costs
(for all pregnancies)
Existing: single screen
Estimate£1 777 469 008£9 697 904£535 434£1 767 235 670
Lower 95% CI
Upper 95% CI
£1 769 393 140
£1 778 772 048
£9 661 636
£9 822 870
£532 820
£545 591
£1 759 111 560
£1 768 490 710
Alternative: repeat screen
Estimate£1 787 355 870£18 860 259£970 254£1 767 525 357
Lower 95% CI
Upper 95% CI
£1 779 322 118
£1 788 703 813
£18 786 836
£19 100 346
£964 636
£989 342
£1 759 402 583
£1 768 782 187
Cost difference£9 886 863£9 162 355£434 820£289 687
  • *Costs to the NHS in the UK for all 725 891 pregnant women screened. Costs are spilt into (1) antenatal screening costs, which includes sample collection and laboratory testing; (2) syphilis treatment within sexual health clinics and (3) perinatal costs, which includes the costs of delivery and neonatal care for all infants.

  • NHS, National Health Service.