Table 1

Treatment schedule for MaPs in ENL.

Time from enrolmentMTX +prednisolone groupPlacebo +prednisolone group
WeekMethotrexate (mg/week)
(MTX tablets will be 2.5 mg)
Prednisolone (mg/day)Prednisolone (mg/day)Dummy methotrexate
(number of tablets/week)
01040404
1–71540406
21535356
31535356
41530306
51530306
61525256
71525256
815/2020206/8
915/2020206/8
1015/2020206/8
1115/2020206/8
1215/2015156/8
1315/2015156/8
1415/2015156/8
1515/2015156/8
1615/2010106/8
1715/2010106/8
1815/20556/8
1915/20556/8
20–4715/20006/8
4810004
4910004
505002
515002
52–590000
  • Participants weighing less than 60 kg will continue to receive 15 mg of MTX weekly and individuals weighing 60 kg or more will receive MTX 20 mg from week 8.

  • ENL, erythema nodosum leprosum; MaPs, methotrexate and prednisolone study; MTX, methotrexate.