Baseline demographic and clinical characteristics of 226 patients with recurrent depression receiving mindfulness-based cognitive therapy who subsequently engaged in full, partial or no discontinuation of maintenance antidepressant medication (mADM) (adapted from Huijbers et al, 2016)
Variable | Total N=226* | Sig. | |||||
Full discontinuation (n=110) | Partial discontinuation (n=34) | No discontinuation (n=82) | |||||
N | % | N | % | N | % | P value | |
Female | 62 | 76 | 18 | 53 | 71 | 64 | 0.048 |
Educational level | 0.421 | ||||||
Low | 7 | 9 | 3 | 9 | 6 | 6 | |
Middle | 24 | 29 | 10 | 29 | 31 | 28 | |
High | 49 | 60 | 21 | 62 | 64 | 58 | |
Missing | 2 | 2 | 0 | 0 | 9 | 8 | |
Marital status | 0.560 | ||||||
Single | 19 | 23 | 6 | 18 | 27 | 25 | |
Married/cohabiting | 46 | 56 | 22 | 65 | 60 | 55 | |
Divorced/widowed | 15 | 18 | 6 | 18 | 16 | 15 | |
Missing | 2 | 2 | 0 | 0 | 7 | 6 | |
Employed (n=225) | 63 | 78 | 22 | 65 | 62 | 56 | 0.009 |
Remission | 0.069 | ||||||
Full, IDS-C ≤11 | 51 | 62 | 17 | 50 | 50 | 45 | |
Partial, IDS-C >11 | 31 | 38 | 17 | 50 | 60 | 55 | |
Type of mADM | 0.669 | ||||||
SSRI | 64 | 78 | 23 | 68 | 21 | 19 | |
TCA | 13 | 16 | 7 | 21 | 21 | 19 | |
Other† | 5 | 6 | 4 | 12 | 6 | 6 | |
Previous CBT treatment | 45 | 55 | 21 | 62 | 68 | 62 | 0.595 |
Suicide attempt (lifetime) | 18 | 22 | 12 | 15 | 21 | 49 | 0.429 |
Mean | SD | Mean | SD | Mean | SD | ||
Age (years) | 50.0 | 11.1 | 52.0 | 9.8 | 51.0 | 10.3 | 0.507 |
Baseline depression (IDS-C) | 10.9 | 8.8 | 12.7 | 11.2 | 14.4 | 10.6 | 0.059 |
Nr. previous episodes | 5.6 | 4.9 | 7.4 | 8.0 | 5.7 | 3.9 | 0.167 |
Age at MDD onset (n=219) | 27 | 11.9 | 25 | 10.8 | 25.0 | 12.3 | 0.388 |
*Excluding 23 of the original 249 trial participants due to missing data regarding discontinuation.
†Including serotonin-norepinephrine reuptake inhibitors, monoamine oxidase-inhibitors and mirtazapine.
CBT, cognitive behavioural therapy; IDS-C, Inventory of Depressive Symptomatology-clinician rated; MDD, major depressive disorder; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.