Table 1

Summary of investigations and assessments

ParticipantsTime points
Intervention (INT) groupUsual care (UC) groupBaseline clinic prior to surgeryDay of surgeryDuring hospital stayDay of hospital discharge1 month after surgery6 months after enrolment
Eligibility and written informed consentXXX
Demographic data*XXX
Previous medical history†XXX
Self-reported quit rateXXXXXXX
Exhaled CO measurementXXXXXXX
NRT and support usage questionnaireXXXXXXX
Fagerstrom test for nicotine dependenceXXXX
Mood and physical symptoms scaleXXXXX
EQ-5D-5LXXX
Health resource usage questionnaireXX
Surgery and anaesthetic data‡XXX
Postoperative complications§ ¶XXXXX
Hospital readmission**XXX
Semistructured qualitative interviews††XXX
Adverse eventsIf applicable
Protocol deviationsIf applicable
  • *Demographic data: gender, age, indication for surgery, height, weight, BMI, ASA grade, ECOG score, dyspnoea score, recent lung function.

  • †Previous medical history: smoking history, alcohol intake per week, comorbidities (COPD, Ischaemic Heart Disease, Congestive Cardiac Failure, Hypertension, diabetes (diet-controlled/oral therapy/insulin), renal failure, previous stroke, thyroid disease (hyperthyroid/ hypothyroid).

  • ‡Operation performed (side of surgery, operation, surgical technique).

  • §Postoperative data and observations: routine blood results if done (full blood count, albumin, renal function, electrolytes, CRP). Acute complications: according to ESTS30 (see online supplemental appendix A) and Thoracic Morbidity and Mortality Classification31 (see online supplemental appendix B), data also collected including admission and length of stay on the ward (0), step-down,1 the HDU2 and ITU.3 Data will also be collected in patients requiring mini-tracheostomy or additional surgery. Postoperative pulmonary complications: using stEP-COMPAC Group definition of postoperative pulmonary complications32 (see online supplemental appendix C) defining atelectasis (detected on computer tomography/CXR), pneumonia (using US Centres for Disease Control criteria), acute respiratory distress syndrome (using Berlin Consensus), and pulmonary aspiration (clear clinical history and radiological evidence).

  • ¶Discharge data: total hospital stay, home with flutter bag, histology data and mortality.

  • **Follow-up: hospital readmission up to and including 1 month following surgery.

  • ††At 4–8 weeks postsurgery patients will also have semistructured qualitative patient interviews will be undertaken at 4 weeks postdischarge to investigate experience, engagement, acceptability, unintended consequences/benefits and how to optimise the intervention delivery.

  • ASA, American Society of Anethesiologist; BMI, body mass index; CO, carbon monoxide; COPD, chronic obstructive pulmonary disease; CRP, C-reactive protein; ECOG, Eastern Cooperative Oncology Group; ESTS, European Society of Thoracic Surgery; HDU, high-dependency unit; INT, intervention integrated; ITU, intensive therapy unit; NRT, nicotine replacement therapy; UC, usual care.