Table 1

Main characteristics of included studies population

Author(s) and yearType of studyCountryParticipants
(n)		Teeth
(n)		Age
(years)		Gender
(n)		Setting
Brugnera et al 199720CCT
split-mouth design		Brazil28112 permanent first molars6–11Not reportedNot reported
Durmus et al 201721RCT
split-mouth design		Turkey51204 permanent first molars7–1027 males
24 females		University Paediatric Dental Clinic
Goodis et al 200422RCT
split-mouth design		USA2474 erupted upper and lower third molars21–3411 males
13 females		University Dental Clinic
Karaman et al 201323RCT
split-mouth design		Turkey16112 teeth (63 molars and 49 premolars)20–231 male
15 females		University Dental Clinic
Kumar et al 201624RCT
split-mouth design		India50200 permanent first molars6–12Not reportedUniversity Paediatric Dental Clinic
Nammour et al 2003 and 200525 26RCT
split-mouth design		Belgium1298 unspecified anterior permanent teethNot reportedNot reportedNot reported
Raucci-Neto et al 201527RCT
split-mouth design		Brazil35416 first and second primary molars7–8Not reportedUniversity Paediatric Dental Clinic
Walsh 199628RCT
split-mouth design		Australia20170 permanent molars and premolars15–3813 males
7 females		University Preventive Dental Clinic
Zezell et al 200929CCT
split-mouth design		Brazil33242 premolars and lower molars7–15Not reportedUniversity Paediatric Dental Clinic

  • CCT, controlled clinical trial; RCT, randomised controlled trial.