Characteristic | Total (n=1001) | Men (n=484) | Women (n=517) | P value* |

Age (years), mean (SD) | 50.8 (12.3) | 50.5 (13.0) | 51.0 (11.6) | 0.583 |

Males, n (%) | 484 (48.4) | − | − | − |

Smoking history, n (%) | 182 (18.2) | 174 (36.0) | 8 (1.5) | <0.001 |

Diabetes mellitus, n (%) | 464 (46.4) | 243 (50.2) | 221 (42.7) | 0.019 |

Antihypertensive medication, n (%) | 544 (54.3) | 273 (56.4) | 271 (52.4) | 0.228 |

Lipid-lowering medication, n (%) | 508 (50.7) | 246 (50.8) | 262 (50.7) | 1.000 |

Body mass index (kg/m^{2}), mean (SD) | 30.9 (6.7) | 29.7 (6.1) | 32.0 (7.0) | <0.001 |

Systolic blood pressure (mm Hg), mean (SD) | 131.0 (17.9) | 133.1 (17.2) | 129.0 (18.4) | <0.001 |

Total cholesterol (mmol/L), mean (SD) | 5.04 (1.12) | 4.97 (1.12) | 5.10 (1.13) | 0.073 |

HDL-C (mmol/L), mean (SD) | 1.14 (0.33) | 1.03 (0.26) | 1.24 (0.34) | <0.001 |

10 years 2008 Framingham risk, median (25th, 75th percentile) | 11.8 (5.1 to 26.6) | 19.4 (8.0 to 38.9) | 7.7 (3.2 to 16.0) | <0.001 |

10 years 2008 Framingham risk ≥20%, n (%) | 334 (33.4) | 240 (49.6) | 94 (18.2) | <0.001 |

10 years 2008 office-based Framingham risk, median (25th, 75th percentile) | 13.9 (5.6 to 32.1) | 22.5 (8.2 to 44.1) | 9.3 (3.7 to 20.5) | <0.001 |

10-year 2008 office-based Framingham risk ≥20%, n (%) | 395 (39.5) | 260 (53.7) | 135 (26.1) | <0.001 |

Observed CVD events, n (%) | 175 (17.5) | 93 (19.2) | 82 (15.9) | |

Incidence rate, CVD cases/1000 person-years | 21.3 | 24.7 | 18.5 |

*The p values were calculated using the independent samples t-test for continuous variables and Fisher’s exact test (two tailed) for categorical variables. The Mann-Whitney U test was used to compare the median values of the 10 years 2008 Framingham model risk and the 10 years 2008 office-based Framingham model risk.

CVD, cardiovascular disease; HDL-C, high-density lipoprotein-cholesterol.;