Table 1

Characteristics of the 2008 Framingham validation cohort

CharacteristicTotal (n=1001)Men (n=484)Women (n=517)P value*
Age (years), mean (SD)50.8 (12.3)50.5 (13.0)51.0 (11.6)0.583
Males, n (%)484 (48.4)
Smoking history, n (%)182 (18.2)174 (36.0)8 (1.5)<0.001
Diabetes mellitus, n (%)464 (46.4)243 (50.2)221 (42.7)0.019
Antihypertensive medication, n (%)544 (54.3)273 (56.4)271 (52.4)0.228
Lipid-lowering medication, n (%)508 (50.7)246 (50.8)262 (50.7)1.000
Body mass index (kg/m2), mean (SD)30.9 (6.7)29.7 (6.1)32.0 (7.0)<0.001
Systolic blood pressure (mm Hg), mean (SD)131.0 (17.9)133.1 (17.2)129.0 (18.4)<0.001
Total cholesterol (mmol/L), mean (SD)5.04 (1.12)4.97 (1.12)5.10 (1.13)0.073
HDL-C (mmol/L), mean (SD)1.14 (0.33)1.03 (0.26)1.24 (0.34)<0.001
10 years 2008 Framingham risk, median (25th, 75th percentile)11.8 (5.1 to 26.6)19.4 (8.0 to 38.9)7.7 (3.2 to 16.0)<0.001
10 years 2008 Framingham risk ≥20%, n (%)334 (33.4)240 (49.6)94 (18.2)<0.001
10 years 2008 office-based Framingham risk, median (25th, 75th percentile)13.9 (5.6 to 32.1)22.5 (8.2 to 44.1)9.3 (3.7 to 20.5)<0.001
10-year 2008 office-based Framingham risk ≥20%, n (%)395 (39.5)260 (53.7)135 (26.1)<0.001
Observed CVD events, n (%)175 (17.5)93 (19.2)82 (15.9)
Incidence rate, CVD cases/1000 person-years21.324.718.5
  • *The p values were calculated using the independent samples t-test for continuous variables and Fisher’s exact test (two tailed) for categorical variables. The Mann-Whitney U test was used to compare the median values of the 10 years 2008 Framingham model risk and the 10 years 2008 office-based Framingham model risk.

  • CVD, cardiovascular disease; HDL-C, high-density lipoprotein-cholesterol.;