Table 1

Study intervention and assessment

BaselineMorning following baseline oximetry1 week2 weeks3–5 weeksTerm equivalent age
Pulse oximetryX XX
RandomisationX    
Loading doseX   
Demographics, contactsX    
Dose adjustment for weight XX
Neonatal salivary caffeine concentration  X 
Maternal salivary caffeine concentration  X 
Drug diaryXXXXX
Compliance assessment  XX
Parental questionnaires:     
Maternal smoking in pregnancy and household smoke exposure questionnaireX    
Sleep questionnaire  XX
Feed tolerance questionnaire  XX
Maternal caffeine intake questionnaireX XX
Edinburgh postnatal depression scaleX   X