Table 1

Study timelines overview of all visits and tests scheduled in the trial

Study period
TimepointEnrolmentFollow-up
Visit 0
week 1
Visit 1
month 1
Visit 2
month 3
Visit 3
month 6
Visit 4
month 12
Enrolment
 Eligibility screen×
 Informed consent×
 Allocation×
Interventions
 Control group××××
 Intervention group××××
Assessments
 Medical history×
 Physical examination×××××
 BP measurement×××××
 Treatment plan×××××
Lab tests
 Blood routine×××
 Serum lipids×××
 Hepatic function×××
 Renal function×××
 FPG×××
 Urine routine×××
ABPM×××
EUROPEP×××××
BMQ×××××
EQ-5D×××××
Cost information×××××
Home BP monitoring compliance×××××
Adverse events××××
  • Hepatic function refers to total bilirubin; alanine aminotransferase; aspartate aminotransferase; gamma glutamine transferase; alkaline phosphatase and albumin. Renal function refers to serum creatinine; blood urea nitrogen and blood uric acid.

  • ABPM, 24-hour ambulatory blood pressure monitoring; BMQ, Brief Medication Questionnaire; BP, blood pressure; EQ-5D, EuroQol five-dimensional; EUROPEP, European Task Force on Patient Evaluations of General Practice; FPG, fasting plasma glucose.